An interventional study of Transcranial direct current stimulation (Anodal) and Transcranial direct current stimulation (Sham) in Transcranial Direct Current Stimulation, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-14.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Basic science
Motor adaptation is guided by state estimation, a dynamic prediction of the interaction consequences between body and environment in the sensorimotor system. Previous studies have shown that the posterior parietal cortex (PPC) and cerebellum are potential candidates for state estimators. However, neither direct evidence linking neural substrates of state estimation and motor adaptation nor the differences in state estimation in these two brain areas was presented. A comparison of neuromodulation effects over PPC and cerebellum in motor adaptation tasks could provide direct evidence to solve the knowledge gap.
Objective: This study aims to provide direct evidence to link state estimation and motor adaptation, and the neuromodulation effects of PPC and cerebellum in motor adaptation by using anodal transcranial direct current stimulation.
This was a single-blind, sham-controlled study. All participants were randomized to the PPC, cerebellum, and sham stimulation group. The ankle tracking system was used to record the ankle tracking visuomotor task during the motor learning phase, motor adaptation phase, and motor re-adaptation phase. Normalized root-mean squared error (RMSE) and RMSE reduction rate were measured as the performance outcome. A 20-minute atDCS at 2 mA anodal tDCS was given during the motor adaptation phase. The immediate effect and after effect of tDCS were seen in the motor adaptation phase and motor re-adaptation phase, respectively.
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In the motor adaptation phase, a 20-minute, 2 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany). The electrical current gradually ramps up and down in 20 seconds. In the PPC group, the anodal electrode was placed over the P3 or P4 areas on the skull, covering the PPC area on the opposite side of the testing foot (according to the international 10-20 EEG system), and the reference electrode was placed over the supraorbital region on the same side of the testing foot.
Device: Transcranial direct current stimulation (Anodal)
In the motor adaptation phase, a 20-minute, 2 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany). The electrical current gradually ramps up and down in 20 seconds. In the cerebellum group, the anodal electrode was placed 1\~2 cm under and 3\~4 cm lateral to the inion on the same side of the testing foot, with the reference electrode placed on the buccinator on the same side of the testing foot.
Device: Transcranial direct current stimulation (Anodal)
In the motor adaptation phase, a 20-minute, 0 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany) for the sham group. Participants were informed that they might experience itchiness, burning, or mild discomfort during the tDCS period regardless of which group they were assigned to, so they would not use their sensation as a basis for determining whether they received actual stimulation or not.
Device: Transcranial direct current stimulation (Sham)
20-minutes, 2 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes
20-minutes, 0 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes
Block root-mean squared error (RMSE)
RMSE is the error between target trajectory and subject cursor trajectory. Every 5 trials of RMSE were averaged into one block.
Time frame: 2 hours during the time of assessment of the participant
RMSE reduction rate
ΔRMSEi-(i+1) = (RMSEi - RMSEi+1) / RMSEi x 100%
Time frame: 2 hours during the time of assessment of the participant
Plan to share: No — undecided
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This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital