An observational study in Malignant Central Nervous System Neoplasm, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-05.
Sponsored by Mayo Clinic · Observational
This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
PRIMARY OBJECTIVES:
I. To establish a Mayo Clinic Florida Brain Tumor-Gut Axis Human Biorepository by sequential collection of fecal, urine, blood, saliva, and/or tissue samples and clinical patient information.
II. To use spatial transcriptome/proteomics/multi-omics coupled with microbiome data from various sources including brain tissue and stool samples to understand how microbiota could impact disease development, progression, and treatment response in patients with brain cancer.
III. To study the effect of microbiome and potential relationships and/or microbiome reconstruction to impact patient's clinical outcomes including chemo, radiation, immunotherapy and/or cellular therapy.
OUTLINE: This is an observational study.
Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study.
673 studies on the registry are indexed under Central Nervous System Neoplasms; 68 are open to participants now.
This study's planned enrollment of 100 is close to the median of 108 across 91 observational studies indexed under Central Nervous System Neoplasms.
Browse Central Nervous System Neoplasms studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
All patients undergoing resection for a tumor of the central nervous system and associated controls are eligible to participate in this study.
Exclusion Criteria:
Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study.
Other: Non-Interventional Study
Non-interventional study
Establish the Mayo Clinic Florida Tumor-Gut Axis Biorepository
Biological samples such as stool, urine, blood, saliva, and/or tissue will be collected for storage in the Tumor-Gut Axis Biorepository. Samples may be collected at any of the following time periods during study participation: before/after steroid therapy, before/after surgical intervention, before/after radiation therapy, and before/after chemotherapy.
Time frame: Approximately 1 year, or until samples have been collected based on scheduled treatment.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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