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Enrolling by invitationNCT06067763Updated Nov 21, 2024

Project Health: Enhancing Effectiveness of an Obesity Prevention Program

An interventional study of Project Health and Response and Attention Training in Overweight and Obesity and Eating Disorders, sponsored by Oregon Research Institute. Enrolling by invitation at 2 sites in United States. Open to participants aged 17 Years to 20 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-11-21.

Sponsored by Oregon Research Institute · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
238
Allocation
Randomized
Ages
17 Years to 20 Years
Sex
All
01

Study summary

This 2-site effectiveness trial will test whether a brief dissonance-based obesity prevention program delivered in single sex groups combined with food response and attention training will produce significantly larger weight gain prevention effects than an educational video control condition. An effectiveness trial is important to test whether this program reduces risk for unhealthy weight gain when delivered by real world clinicians under ecologically valid conditions, which is an important step toward broad implementation. A secondary aim focuses on eating disorder symptom prevention effects. A sample of 17-20 year olds with weight concerns (N = 120) will be randomized to single sex Project Health groups with food response and attention training or an educational video control condition. Participants will complete assessments at baseline, posttest, and 6- and 12-month follow ups.

Read the detailed description

In the previous Project Health trial, the investigators found Project Health is most effective when implemented in single sex groups paired with food specific response and attention training. This project will evaluate the effectiveness of this version of the Project Health intervention compared to a video control condition and is an important step toward dissemination. A brief effective obesity prevention program that can be easily, inexpensively, and broadly implemented to late adolescents at risk for excess weight gain, as has been the case with another dissonance-based prevention program, could markedly reduce the prevalence of obesity and associated morbidity and mortality. The program may also have an important secondary benefit of preventing the onset of future eating symptoms and disorders. The study has 2 aims: (1) Test the hypothesis that Project Health implemented in single-sex groups and paired with food response inhibition and attention training produces significantly larger weight gain and overweight/obesity onset prevention effects than an educational video control condition (primary outcome). (2) Test the hypothesis that Project Health implemented in single-sex groups and paired with food response inhibition and attention training produces significantly larger eating disorder symptom prevention effects than an educational video control condition (secondary outcome).

02

Conditions studied

  • Overweight and Obesity
  • Eating Disorders

Keywords

  • obesity
  • overweight
  • eating disorders
  • prevention
  • adolescent
  • dissonance
03

Who can participate

Ages eligible
17 Years to 20 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Current at least moderate weight concerns (defined as a response of 4 or above on an 8 point scale ranging from none (0) to extreme (8))
  • Self-reported room for improvement in diet and exercise habits (response of yes to "Do you believe there is room for improvement in your diet and exercise habits?" in the pre-screening questionnaire)
  • BMI greater than or equal to 20 and less than or equal to 30
  • Age between 17 and 20 years old

Exclusion criteria

Exclusion Criteria:

  • Current diagnosis of anorexia nervosa, bulimia nervosa or binge eating disorder
  • Previous participation in a Project Health study
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
238 participants (estimated)

Study arms

  • Experimental
    Female Group, Food Response Training

    Participants in this arm will be assigned to receive Project Health in female-only groups and will complete the food-focused response and attention training intervention.

    Behavioral: Project Health · Behavioral: Response and Attention Training

  • Experimental
    Male Group, Food Response Training

    Participants in this arm will be assigned to receive Project Health in male-only groups and will complete the food-focused response and attention training intervention.

    Behavioral: Project Health · Behavioral: Response and Attention Training

  • Active comparator
    Educational Video control

    Participants in this arm will be assigned to watch a four-part documentary "The Weight of the Nation" from their home.

    Other: The Weight of the Nation

Interventions

  • BehavioralProject Health

    A brief dissonance-based obesity prevention program delivered in six one-hour weekly sessions.

  • BehavioralResponse and Attention Training

    Individualized, computerized response and attention training consisting of five separate tasks designed to increase inhibitory control to reduce overeating.

  • OtherThe Weight of the Nation

    This 2012 documentary discusses the facts and myths about obesity and the impacts of obesity on individuals and the health care system in the United States.

05

What researchers measure

Primary outcomes

  1. Body Fat

    Change in percentage of body fat as measured by air displacement plethysmography (ADP) via the Bod Pod.

    Time frame: baseline, posttest (approximately 8 weeks after baseline), 6-month follow-up (approximately 34 weeks after baseline), 12-month follow-up (approximately 60 weeks after baseline)

Secondary outcomes

  1. Eating Disorder Symptoms

    The Eating Disorder Diagnostic Interview, a brief semi-structured interview will assess eating disorder symptoms. It provides diagnoses for anorexia nervosa, bulimia nervosa, and binge eating disorder. It also provides a continuous measure of overall eating disorder symptoms.

    Time frame: baseline, posttest (approximately 8 weeks later), 6-month follow-up (approximately 34 weeks after baseline), 12-month follow-up (approximately 60 weeks after baseline)

06

Study locations

2 sites
  • Stanford University
    Stanford, California 94305, United States
  • Oregon Research Institute
    Springfield, Oregon 97477, United States
07

References and documents

Individual participant data

Plan to share: Yes — The investigators will share all study data via the NICHD Data and Specimen Hub (DASH), which is the centralized resource for researchers to store and access data from NICHD-funded research studies to use for secondary research. All data, with the exception of video recordings of the participants in treatment (which cannot be effectively de-identified), will be provided.

Supporting information: Study protocol, Icf, Csr

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06067763
Lead sponsor
Oregon Research Institute
Collaborators
Stanford University, Drexel University
Responsible party
Sponsor
First posted
Oct 5, 2023
Start date
Jan 30, 2020
Primary completion
Jul 31, 2025 (estimated)
Completion
Jul 31, 2025 (estimated)
Last update
Nov 21, 2024

Study contacts

Eric Stice, PhD
principal investigator · Stanford University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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