An observational study in Aging, sponsored by University of Nottingham. Completed at 1 site in United Kingdom. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-03.
Sponsored by University of Nottingham · Observational
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength (HGS) and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET).
Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.
University of Nottingham is the lead sponsor of 455 studies on the registry; 77 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Community dwelling adults over the age of 65y who were able to provide written, informed consent and had no contraindications to exercise testing.
Exclusion Criteria:
Cardiorespiratory fitness (CRF) - VO2 max
CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test.
Time frame: Single time-point - 8 to 12 minutes
Cardiorespiratory fitness (CRF) - Anaerobic threshold
CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test.
Time frame: Single time-point - 8 to 12 minutes
Muscle architecture - muscle thickness
Analysis of vastus lateralis muscle thickness using b-mode ultrasonography
Time frame: Single time-point: 10 minutes
Muscle architecture - pennation angle
Analysis of vastus lateralis pennation angle using b-mode ultrasonography
Time frame: Single time-point: 10 minutes
Muscle architecture - fascicle length
Analysis of vastus lateralis fascicle length using b-mode ultrasonography
Time frame: Single time-point: 10 minutes
Plan to share: No
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This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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University of Nottingham