An interventional study of sequential fecal microbiota transplant combined with small intestinal fluid transplant in Intestinal Pseudo-Obstruction and Fecal Microbiota Transplantation, sponsored by Shanghai 10th People's Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2023-08-31.
Sponsored by Shanghai 10th People's Hospital · Not applicable, Interventional, and Treatment
Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare gastrointestinal disorder that primarily affects the movement of the intestines, leading to symptoms that resemble a true bowel obstruction but without a physical blockage. This condition is characterized by impaired motility of the gastrointestinal tract, which can result in severe symptoms and complications. In previous studies, the investigator found that sequential microbiota transplantation therapy can improve clinical symptoms of chronic pseudo-obstruction. Building on this foundation, the current study further investigates the effects of sequential interventions involving intestinal cleansing, small intestine bacterial treatment, fecal microbiota transplantation, and nutritional therapy on the short-term and long-term clinical symptom improvement in patients. Additionally, the investigator aim to elucidate the changes in gut microbiota phenotypes before and after treatment.
26 studies on the registry are indexed under Intestinal Pseudo-Obstruction; 9 are open to participants now.
This study's enrollment of 10 is below the median of 61 across 18 interventional studies indexed under Intestinal Pseudo-Obstruction.
Browse Intestinal Pseudo-Obstruction studies →Shanghai 10th People's Hospital is the lead sponsor of 167 studies on the registry; 45 are open to participants now.
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Exclusion Criteria:
Other: sequential fecal microbiota transplant combined with small intestinal fluid transplant
for eligible patients, the investigator use rifaximin, three times daily, 0.4 g each time, lasting 6 days followed by fecal microbiota transplant combined with small intestinal fluid transplant for 6 days. These procedures were repeated every 28 days.
Enteral Nutrition Tolerance
the maximal amount of enteral nutrition allowed daily
Time frame: 8 weeks
Nutrition Status
intersectional muscle and fat area measurements by quantitative computed tomography
Time frame: 52 weeks
Need for surgery
Surgical interventions are performed due to intestinal nutritional intolerance, including procedures such as nutritional ostomy, decompression ostomy, and intestinal resection.
Time frame: 52 weeks
Changes of both colerectal and small intestinal microbiota profile
Both colorectal and small intestinal bacteria profile before and after treatment.
Time frame: 8 weeks
Plan to share: Yes
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Intestinal Pseudo-Obstruction→
Shanghai 10th People's Hospital