An observational study in Parkinson Disease, Deep Brain Stimulation and Non-motor Symptoms, sponsored by Tianjin Huanhu Hospital. Not yet recruiting. Open to participants aged Up to 75 Years. Per ClinicalTrials.gov, last updated 2023-07-25.
Sponsored by Tianjin Huanhu Hospital · Observational
As a surgical intervention, DBS can effectively relieve PD tremor, rigidity, bradykinesia and other symptoms. How to better screen patients suitable for DBS treatment and conduct reasonable preoperative and postoperative evaluation is crucial to judge the treatment effect and prognosis. The clinical symptom evaluation of PD patients can be divided into motor symptom evaluation and non-motor symptom evaluation. The motor symptoms of PD patients were evaluated by UPDRS III. The evaluation of non-motor symptoms in PD patients was mainly divided into three aspects: cognitive status, emotional status, and sleep status. Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive status of PD patients. The Hamilton Depression Scale (HAMD) was used to assess the patients' depression status. The Hamilton Anxiety Scale (HAMA) was used to assess the patients' anxiety status. The PD Sleep Scale 2nd version, The PD Sleep Scale 2nd version, PDSS - 2), and rem Sleep Behavior Disorder Questionnaire (sweet HK) (Rapid Eye Movement Sleep behaviors Disorder Questionnaire - Hong Kong, RBDQ - HK) to assess Sleep conditions.
4,583 studies on the registry are indexed under Parkinson Disease; 1,097 are open to participants now.
This study's planned enrollment of 100 is close to the median of 97 across 1,081 observational studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Tianjin Huanhu Hospital is the lead sponsor of 26 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with primary Parkinson's disease were followed up for 1 year after deep brain stimulation, and the imaging data were intact
Inclusion Criteria:The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, age under 75, acute levodopa motor response ≥30%, and indication for STN-DBS. -
Exclusion Criteria: patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery -
We observed whether the symptoms of patients improved after DBS surgery and divided them into groups.
Procedure: DBS
Procedure: DBS
We observed the prognostic changes of patients after DBS surgery
motor symptom
UPDRS III score changes
Time frame: 2023.1 to 2025.12
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Aug 2023; primary completion for Sep 2026, 37 months later.
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This study is not yet recruiting, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.
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Tianjin Huanhu Hospital