An interventional study of Nasogastric aspiration for measurement of Residual Gastric Volume and Nasogastric Aspiration for Measurement of Gastric pH in Pulmonary Aspiration of Gastric Contents, sponsored by King Edward Medical University. Completed at 1 site in Pakistan. Open to participants aged 1 Year to 12 Years. Per ClinicalTrials.gov, last updated 2023-06-28.
Sponsored by King Edward Medical University · Not applicable, Interventional, and Prevention
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
Pre-operative fasting is a specific time period before a procedure in which participants will be advised not to take any liquid or solid by mouth. Nil per oral (NPO) is a universally accepted practice before elective general anesthesia in order to reduce gastric contents aspiration. In the period of chloroform anesthesia NPO was introduced because of vomiting and discomfort associated with anesthesia. Hence prevention from aspiration of gastric contents was a main focus during general anesthesia. With introduction of better anesthesia drugs recommendations were given to keep minimal fasting time before general anesthesia.
Recent guidelines suggest six, four and two hours fasting for solids/ infant formula milk, breast milk and clear fluids respectively. It is common practice to keep children NPO for 6 hours before surgery. But many times, children have to suffer excessive unnecessary fasting due to delayed surgery that lead to reduction in systolic blood pressure, induce catabolic state and behavioral effects. Moreover prolonged fasting increases insulin resistance and may increase the inflammatory response to surgery.
28 studies on the registry are indexed under Respiratory Aspiration of Gastric Contents; 6 are open to participants now.
This study's enrollment of 120 is close to the median of 113 across 16 interventional studies indexed under Respiratory Aspiration of Gastric Contents.
Browse Respiratory Aspiration of Gastric Contents studies →King Edward Medical University is the lead sponsor of 78 studies on the registry; 24 are open to participants now.
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Exclusion Criteria:
1.Patients with co-morbidities like acid peptic disease with history of dyspepsia and family history or self-history of diabetes mellitus.
6,4 and 2 hours NPO for solids/ formula milk, breast milk and clear fluid respectively
Procedure: Nasogastric aspiration for measurement of Residual Gastric Volume · Procedure: Nasogastric Aspiration for Measurement of Gastric pH
6,4 and 1-hour NPO for solids/ formula milk, breast milk and clear fluid respectively
Procedure: Nasogastric aspiration for measurement of Residual Gastric Volume · Procedure: Nasogastric Aspiration for Measurement of Gastric pH
The patients enrolled in this study undergoing elective general anesthesia,their mean gastric residual volume will be measured by taking Nasogastric tube aspirate.
The patients enrolled in this study undergoing elective general anesthesia,their mean gastric gastric PH will be measured by taking Nasogastric tube aspirate.
Mean residual gastric volume
Mean Residual Gastric Volume will be measured in mililiter
Time frame: 6 Months
Gastric pH
Gastric pH will be measured by pH Litmus paper
Time frame: 6 months
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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Respiratory Aspiration of Gastric Contents→
King Edward Medical University