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CompletedNCT05921357EFFPCFPDHUpdated Feb 4, 2025

Effect of Fermented Products and Probiotics on the Condition of the Implant

An observational study in Implant, sponsored by Tuğba ŞAHİN. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-02-04.

Sponsored by Tuğba ŞAHİN · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
126
Ages
18 Years to 70 Years
Sex
Female
01

Study summary

126 individuals with peri-implant disease and health, aged between 18-70 years, who applied to Bolu University Faculty of Dentistry Periodontology Clinic, participated in the study.The inclusion criteria for patient participation in the study were: age of patients between 18 and 70 years; the presence of at least 20 natural teeth in the oral cavity; systemic health. Peri-implant status was determined by the clinician (T.Ş.) by evaluating dental implants' plaque, gingival index, bleeding on probing, pocket depth measurements, and clinical attachment level. In addition, them systemic illness, pregnancy, breastfeeding status, medication, antibiotic use, and whether they smoked were questioned. Systemically unhealthy patients who did not use antibiotics within a month, were breastfeeding or pregnant, had uncontrolled diabetes, rheumatic fever, a history of lung and kidney disorders, and used drugs that could affect periodontal tissues were not included in the study. After examination, the patients were divided into three groups according to their disease: Peri-implantitis (42 patients), peri-implantitis (42 patients), and peri-implant health (42 patients). Demographic characteristics (age, weight, gender, height, education, and employment status) of the participants were collected with a questionnaire. With this survey, fermented foods and probiotic products such as bacon, soy sauce, pickles, sourdough bread, whole grain, rye, wholemeal bread, ayran, kefir, turnip, vinegar (homemade), pomegranate syrup (homemade), probiotic beverage, the frequency and amount of consumption of cheese, dark chocolate, tablets, capsules, chassis, butter and other (Kimchi, sauerkrauth, miso soup, fermented herring, kombucha, etc.) were determined. It was requested to determine the relationship between the health and disease of the implant and the frequency of consumption of fermented and probiotic products and foods in individuals with implants.

02

Conditions studied

  • Implant

Keywords

  • Fermented foods
  • probiotics
  • peri-implant health
  • peri-implant mucositis
  • peri-implantitis
03

In context

Lead sponsor

Tuğba ŞAHİN is the lead sponsor of 7 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Bolu Abant İzzet Baysal University

Inclusion criteria

  • Systemically healthy individuals
  • Individuals between the ages of 18-70

Exclusion criteria

Exclusion Criteria:

  • No use of antibiotics within one month
  • Breastfeeding or being pregnant
  • Uncontrolled diabetes, rheumatic fever, history of lung and kidney disorders, and drug use that will affect periodontal tissues
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
126 participants (actual)
Patient registry
No

Groups and cohorts

  • Peri-implantitis

    Implants with a pocket depth of more than 5 mm and bleeding on probing

    Other: Questionnaire

  • Peri-implant mucositis

    Implants with no bone loss but bleeding on probing

    Other: Questionnaire

  • Peri-implant health

    Implants with no bone loss but no bleeding on probing

    Other: Questionnaire

Interventions

  • OtherQuestionnaire

    Questionnaire and examine

06

What researchers measure

Primary outcomes

  1. Consumption frequency

    the number of times a product is consumed in a given time period.

    Time frame: Baseline

  2. Consumption amount

    The average quantity of an item consumed or expended during a given time interval, expressed in quantities by the most appropriate unit of measurement per applicable stated basis.

    Time frame: Baseline

  3. Daily intake

    The amount of a substance that people can consume on a daily basis

    Time frame: Baseline

  4. Bleeding on probing

    Bleeding, leading sign of inflammation inside the connective tissue, is a critical factor for pocket depth measurements, and with other variable factors prevents making reproducible measurements.

    Time frame: Baseline

  5. Periodontal pocket depth

    a pathologically deepened gingival sulcus around a tooth at the gingival margin.

    Time frame: Baseline

Secondary outcomes

  1. Plaque index

    The plaque index assesses the amount of dental plaque visible on the vestibular and lingual surfaces of all teeth

    Time frame: Baseline

  2. Gingival index

    This measurement is based on the presence or absence of bleeding on gentle probing.

    Time frame: Baseline

  3. Clinical attachment level

    CAL is calculated by subtracting the gingival margin level from the probing depth.

    Time frame: Baseline

07

Study locations

1 site
  • Bolu Abant İzzet Baysal University
    Bolu, Turkey
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05921357
Lead sponsor
Tuğba ŞAHİN
Responsible party
Tuğba ŞAHİN (Assistant professor, Abant Izzet Baysal University) — Sponsor-investigator
First posted
Jun 27, 2023
Start date
Jul 4, 2022
Primary completion
Jul 4, 2022
Completion
Mar 31, 2023
Last update
Feb 4, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

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