An interventional study of Repetitive transcranial magnetic stimulation and Sham repetitive transcranial magnetic stimulation in Transcranial Magnetic Stimulation, sponsored by Yi Yang. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-02-29.
Sponsored by Yi Yang · Not applicable, Interventional, and Treatment
The purpose of this study was to investigate the effect of high-frequency repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with cerebral small vessel disease.
Current studies have shown that repetitive transcranial magnetic stimulation can change the excitability of nerve cells, improve intracerebral artery blood supply, and even reduce the degree of neurological impairment in patients with stroke. The purpose of this study was to investigate the effect of high-frequency repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with cerebral small vessel disease.
121 studies on the registry are indexed under Cerebral Small Vessel Diseases; 66 are open to participants now.
This study's planned enrollment of 80 is close to the median of 84 across 69 interventional studies indexed under Cerebral Small Vessel Diseases.
Browse Cerebral Small Vessel Diseases studies →Yi Yang is the lead sponsor of 41 studies on the registry; 25 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients are treated with repetitive transcranial magnetic stimulation (rTMS).
Procedure: Repetitive transcranial magnetic stimulation
Patients are treated with sham repetitive transcranial magnetic stimulation (sham-rTMS).
Procedure: Sham repetitive transcranial magnetic stimulation
After enrollment, the patients received rTMS once a day for 5 consecutive days (stimulation plan: stimulation of M1 region on the affected side at 10Hz).
After enrollment, the patients received sham-rTMS once a day for 5 consecutive days with the same parameters as the rTMS group, but the coil was rotated 90° away from the scalp.
phase difference (PD) in degree
A cerebral autoregulation parameter derived from transfer function analysis. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the cerebral autoregulatory parameter.
Time frame: 0-5 days
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Cerebral Small Vessel Diseases→
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