An interventional study of Checkpoint BEST System in Nerve Injury, Peripheral Nerve Injuries and Peripheral Nerve Injury Upper Limb, sponsored by Checkpoint Surgical Inc.. Completed at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by Checkpoint Surgical Inc. · Not applicable, Interventional, and Treatment
This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for peripheral nerve injury in arm. Participants will be randomized into one of two groups, treatment or control, with all participants receiving standard of care treatment for the nerve injury. The treatment group will also receive a single dose of the therapeutic stimulation during the surgical intervention for their nerve injury.
Preliminary research has shown that delivering a brief period of electrical stimulation following nerve repair promotes nerve healing and functional recovery. This pilot study is investigating the use of a single dose of therapeutic electrical stimulation to promote nerve healing. The therapy is delivered as part of the surgical intervention to address peripheral nerve injury in the arm.
87 studies on the registry are indexed under Peripheral Nerve Injuries; 20 are open to participants now.
This study's enrollment of 13 is below the median of 44 across 58 interventional studies indexed under Peripheral Nerve Injuries.
Browse Peripheral Nerve Injuries studies →Checkpoint Surgical Inc. is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Single, 10 minute dose of electrical stimulation delivered to the injured nerve during surgical intervention.
Device: Checkpoint BEST System
Surgical intervention for repair of peripheral nerve injury.
Single use medical device, consisting of electric stimulator and intraoperative lead. Therapy consists of single, 10 minute dose delivered proximal to site of decompression/repair
Also known as: Brief Electrical Stimulation (BES) Therapy
Change in Motor Recovery assessed using the Medical Research Council (MRC) motor grading
Grading of muscle strength on 0 to 5 scale, with higher score representing greater function.
Time frame: Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Grip Strength
Maximum grip strength.
Time frame: Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Lateral Pinch Strength
Maximum lateral pinch.
Time frame: Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
2-point discrimination
Evaluation of sensory function, measuring tactile discrimination.
Time frame: Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Semmes-Weinstein Monofilament Testing
Evaluation of sensory function, measuring pressure detection threshold.
Time frame: Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Patient Reported Outcome Measurement System (PROMIS) Upper Extremity Function
Questionnaire providing patient reported estimate of upper extremity function on a 0-100 scale with \>50 representing greater normal function.
Time frame: Pre-surgery, 10 days, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Patient Reported Outcome Measurement System (PROMIS) Pain Interference
Questionnaire providing patient reported estimate of interference of pain on daily activities on a 0-100 scale with \>50 representing greater than normal pain interference on daily activities.
Time frame: Pre-surgery, 10 days, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
quick Disabilities of thee Arm, Shoulder, and Hand (DASH) questionnaire
Questionnaire providing patient reported estimate upper extremity function. The score ranges from 0 (no disability) to 100 (most severe disability).
Time frame: Pre-surgery, 10 days, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months
Electromyography (EMG)
Measurement of the electrical activity in a muscle.
Time frame: 4 months, 6 months, and 8 months
Motor Unit Number Estimation (MUNE)
Estimate of the number of motor units within the muscle based on recorded electrical activity.
Time frame: 4 months, 6 months, and 8 months
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Checkpoint Surgical Inc.