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CompletedNCT05867719Updated May 4, 2026

The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks

An interventional study of Hypoxic breathing conditions in Altitude Hypoxia, sponsored by University of Texas, El Paso. Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-04.

Sponsored by University of Texas, El Paso · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
17
Allocation
Non-randomized
Ages
18 Years to 40 Years
Sex
All
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Study summary

  • The purpose of this study is to investigate which physiological process that controls normal human body homeostasis is affected by low levels of acute hypoxic exposure and whether there is a difference in those physiological processes and simulated flight performance between a rapid and ramp hypoxic exposure. To accomplish this, pilot analogs will be exposed to normoxic, simulated 8,000 ft (2438 m), simulated 12,000 ft (3658 m), and a ramp exposure breathing at simulated 8,000 ft for 5 minutes before ascending to simulated 12,000 ft while flying in a flight simulator. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target. Physiological measures of heart rate variability (HRV), blood pressure (BP), peripheral oxygen saturation (SpO2), electrodermal activity (EDA), and neck neuromuscular activity using electromyography (EMG) will be measured for this study. Along with questionnaires to assess hypoxic symptoms, simulator sickness, and self-perceived workload for each task
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Conditions studied

  • Altitude Hypoxia

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03

In context

Altitude Sickness

189 studies on the registry are indexed under Altitude Sickness; 44 are open to participants now.

This study's enrollment of 17 is below the median of 33 across 157 interventional studies indexed under Altitude Sickness.

Browse Altitude Sickness studies →

Lead sponsor

University of Texas, El Paso is the lead sponsor of 20 studies on the registry; 11 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Meets body composition standards for the US Navy Active-duty personnel based on height and weight
  • Normal vision/corrected to normal vision

Exclusion criteria

Exclusion Criteria:

  • Respiratory Deficiencies
  • Cardiovascular Disorders
  • Neurological/Musculoskeletal Disorders
  • Photosensitive Epilepsy
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
17 participants (actual)

Study arms

  • No intervention
    Normoxic

    Participants will complete three flight simulator tasks at a normoxic (baseline) altitude. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target.

  • Experimental
    Simulated 8,000 feet hypoxic

    Participants will complete three flight simulator tasks at a simulated 8,000 foot altitude. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target.

    Other: Hypoxic breathing conditions

  • Experimental
    Simulated 12,000 feet hypoxic

    Participants will complete three flight simulator tasks at a simulated 12,000 foot altitude. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target.

    Other: Hypoxic breathing conditions

  • Experimental
    Ramp hypoxic exposure

    Participants will complete three flight simulator tasks in a ramp exposure breathing at simulated 8,000 feet for five minutes before ascending to simulated 12,000 feet while flying in a flight simulator. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target.

    Other: Hypoxic breathing conditions

Interventions

  • OtherHypoxic breathing conditions

    Participants will undergo three separate hypoxic conditions, along with a normoxic condition, simulating 8,000 foot elevation, 12,0000 foot elevation, and a ramp condition starting at 8,000 feet and then ascending to 12,000 feet.

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What researchers measure

Primary outcomes

  1. Flight performance

    ability to perform in-flight assigned tasks

    Time frame: 10 minutes per each of the 4 conditions

  2. Self-perceived workload

    NASA TLX survey

    Time frame: 1 minute to complete the survey, 3 times per condition for 4 conditions

  3. Electrodermal activity

    electrical characteristics of the skin observed as changes in the resistance of the skin to a small electrical current

    Time frame: 10 minutes per each of the 4 conditions

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Study locations

1 site
  • University of Texas at El Paso
    El Paso, Texas 79902, United States
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05867719
Lead sponsor
University of Texas, El Paso
Responsible party
Jeffrey Eggleston (Assistant Professor of Kinesiology, University of Texas, El Paso) — Principal investigator
First posted
May 22, 2023
Start date
Aug 1, 2023
Primary completion
Apr 27, 2026
Completion
Apr 27, 2026
Last update
May 4, 2026

Study contacts

Jeffrey Eggleston, PhD
principal investigator · Associate Professor

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.

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