An interventional study of Repetitive Transcranial Magnetic Stimulation (rTMS) and Gait training in Mild Cognitive Impairment, sponsored by University of Florida. Not yet recruiting. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by University of Florida · Not applicable, Interventional, and Basic science
The purpose of this study is to evaluate the feasibility of combining repetitive transcranial magnetic stimulation (rTMS), gaze and gait training to improve walking and balance in people with or without mild cognitive impairment.
The study plan is to recruit a total of 15 cognitively impaired and 15 healthy adults. The study will involve two visits. Each study visit will involve:
Researchers will compare changes in gaze and gait following training sessions with real rTMS and sham rTMS.
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's planned enrollment of 30 is below the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →University of Florida is the lead sponsor of 1,254 studies on the registry; 201 are open to participants now.
Of its 170 completed or terminated interventional studies of FDA-regulated products, 136 (80%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will receive 1 hour of real rTMS followed by 1 hour of gaze and gait training.
Device: Repetitive Transcranial Magnetic Stimulation (rTMS) · Behavioral: Gait training · Behavioral: Gaze training
Participants will receive 1 hour of sham rTMS followed by 1 hour of gaze and gait training.
Behavioral: Gait training · Behavioral: Gaze training · Device: Sham rTMS
10 Hz rTMS for 5 seconds over the frontal eye fields with 25 second intertrain interval for 10 trains (500 pulses) at 90% of the resting motor threshold,
Also known as: 10 Hz rTMS FEF
Subjects will practice stepping on virtual targets with real-time feedback of their foot position displayed on a screen while walking on a treadmill.
Subjects will perform gaze stabilization and gaze shifting exercise via a virtual reality headset.
Sham rTMS stimulation will produce discharge noise and vibration without stimulating the cerebral cortex.
Change in Foot Placement Error from baseline 1
Foot position relative to stepping targets.
Time frame: Beginning and end of Visit 1, an average of 8 hours
Change in VOR Gain from baseline 1
The amount of eye relative to head movement during active head rotations.
Time frame: Beginning and end of Visit 1, an average of 8 hours
Change in Foot Placement Error from baseline 2
Foot position relative to stepping targets.
Time frame: Beginning and end of Visit 2, an average of 8 hours
Change in VOR Gain from baseline 2
The amount of eye relative to head movement during active head rotations.
Time frame: Beginning and end of Visit 2, an average of 8 hours
Change in Timed Up and Go (TUG) from baseline 1
The TUG assesses mobility, balance, waking ability and fall risk in older adults. A higher risk for falling is indicated by \>= 12 seconds to complete the test.
Time frame: Beginning and end of Visit 1, an average of 8 hours
Change in Timed Up and Go (TUG) from baseline 2
The TUG assesses mobility, balance, waking ability and fall risk in older adults. A higher risk for falling is indicated by \>= 12 seconds to complete the test.
Time frame: Beginning and end of Visit 2, an average of 8 hours
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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University of Florida