An interventional study of Ziacom Galaxy dental implant with internal connical prosthetic connection and Ziacom Zinic dental implant with internal hexagonal prosthetic connection in Jaw, Edentulous, Partially, sponsored by Universidad de Granada. Active, not recruiting at 1 site in Spain. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by Universidad de Granada · Not applicable, Interventional, and Treatment
Dental implants may suffer from bone loss around them, particularly at the upper portion where the prosthesis starts. The connection between both parts of the tooth restoration is key for avoiding micromovement during chewing, bacterial contamination and initiation of bone loss. Thus, investigating factors related to this bone loss in different types of implant-prosthetic connections is key for promoting better use of available therapeutics devices. In this study, we will study marginal bone levels over time as well as bacterial contamination and inflammatory markers in the peri-implant sulcus around implants with connical connection and compare them with those obtained when using implants with internal hexagonal connection. The hypothesis is that bone loss will be higher in implants with hexagonal connection associated with a pathological microbiome in the sulcus that induces a higher inflammatory response.
66 studies on the registry are indexed under Jaw, Edentulous, Partially; 7 are open to participants now.
This study's planned enrollment of 42 is above the median of 36 across 58 interventional studies indexed under Jaw, Edentulous, Partially.
Browse Jaw, Edentulous, Partially studies →Universidad de Granada is the lead sponsor of 241 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Placement and restoration of a single Ziacom Galaxy dental implant with internal connical prosthetic connection
Device: Ziacom Galaxy dental implant with internal connical prosthetic connection
Placement and restoration of a single Ziacom Zinic dental implant with internal hexagonal prosthetic connection
Device: Ziacom Zinic dental implant with internal hexagonal prosthetic connection
Placement and restoration of a single Ziacom Galaxy dental implant with internal connical prosthetic connection
Placement and restoration of a single Ziacom Zinic dental implant with internal hexagonal prosthetic connection
Marginal bone level
Time frame: 1 year
Peri-implant microbiome
Relative abundance of microbial species in the peri-implant sulcus evaluated by next-generation sequencing methods
Time frame: 1 year
Peri-implant inflammation
Concentration of pro-inflammatory markers in the peri-implant sulcus evaluated by multiplex techniques methods
Time frame: 1 year
Plan to share: No
This study is active, not recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Universidad de Granada