An interventional study of ≥ 2 eggs in addition to usual diet for 8 weeks and ≥ 2 eggs in addition to usual diet for 4 weeks in Cancer and Other Malnutrition, sponsored by University of Alberta. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-18.
Sponsored by University of Alberta · Not applicable, Interventional, and Supportive care
Cancer and its treatments often result in severe toxicities and side effects that, over the course of treatment, results in weight loss and depletion of key nutrients. Loss of muscle mass and strength during cancer treatment is a critical problem because it negatively affects patient response and tolerance to therapy and post-treatment recovery. To restore the nutritional status, it is imperative to stimulate muscle protein anabolism. Eggs are high quality protein source, popular and well tolerated by cancer patients. Therefore, the objective of this study is to determine whether a nutritional intervention of ≥2 eggs can aid in restoring nutritional status and improving immune function and quality of life of cancer patients' post-treatment. It is an 8- week randomised clinical trial with parallel arm assignment. Half of the participants will receive the nutritional intervention (Early Intervention) and the other half will be on standard of care or usual diet for first 4 weeks. Starting from week 5, all participants will receive the nutrition intervention till week 8 (Delayed Intervention). Dietary intake (foods and nutrients), cumulative protein intake (g protein/kg body weight), immunological measures, physical performance and quality of life has been planned to be assessed over time and between groups to evaluate the feasibility of an egg intervention in meeting recommended protein intakes for patients with cancer.
9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.
This study's enrollment of 2 is below the median of 50 across 7,253 interventional studies indexed under Neoplasms.
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Exclusion Criteria:
Participants are expected to begin intervention immediately after the completion of treatment for a period of 8 weeks.
Other: ≥ 2 eggs in addition to usual diet for 8 weeks
Participants are expected to begin intervention 4 weeks after the completion of the treatment, for a period of 4 weeks (weeks 5-8).
Other: ≥ 2 eggs in addition to usual diet for 4 weeks
Participants are expected to consume≥ 2 eggs per day in addition to usual diet for 8 weeks in early intervention arm, beginning immediately post-treatment.
Participants are expected to continue intake of regular diet beginning immediately at post-treatment recovery for a duration of 4 weeks, then crossover to nutritional intervention arm from weeks 5 to 8 of post-treatment recovery for a duration of 4 weeks.
Difference in mean cumulative protein intake between the two groups at 8 weeks.
Mean cumulative protein intake will be arrived at by normalizing protein intake in kilocalories by body weight in kilograms
Time frame: From baseline at 8 weeks
Difference in mean cumulative protein intake within a group at 8 weeks for each group.
Mean cumulative protein intake will be arrived at by normalizing protein intake in kilocalories by body weight in kilograms
Time frame: From baseline at 8 weeks
Change in Energy Intake
Energy intake can be described as energy intake in kilocalories normalized by body weight in kilograms.
Time frame: From baseline at 8 weeks
Change in Body weight
in kilograms
Time frame: From baseline at 8 weeks
Change in Quality of Life
Research and Development(RAND) Short Form 36-Item Health Survey 1.0 Minimum to Maximum score= 0 to 100 High Score indicates more favorable outcome.
Time frame: From baseline at 8 weeks
Change in Nutritional status and Symptom severity.
Patient generated-subjective global assessment (PG-SGA), 0-9 point score, higher the score more severe the malnourishment. Edmonton Symptom Assessment Scale- Revised (ESAS-r, 0 to 10 Visual analog scale, higher the number more severe the symptom)
Time frame: From baseline at 8 weeks
Change in Quality of Life related to malnutrition
Functional assessment of Anorexia-Cachexia Therapy 5 question Anorexia/ Cachexia subscale (FAACT A/C Subscale, Score Range= 0 to 20, Higher the score better the quality of life)
Time frame: From baseline at 8 weeks
Change in Physical performance
Short physical performance battery (SPPB, Score range= 0 to 12, higher the score better the performance)
Time frame: From baseline at 8 weeks
Plan to share: No
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This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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University of Alberta