An interventional study of Repetitive transcranial magnetic stimulation and Sham repetitive transcranial magnetic stimulation in Transcranial Magnetic Stimulation, sponsored by Yi Yang. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-30.
Sponsored by Yi Yang · Not applicable, Interventional, and Treatment
The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
Current studies have shown that repetitive transcranial magnetic stimulation can change the excitability of nerve cells, improve intracerebral artery blood supply, and even reduce the degree of neurological impairment in patients with ischemic stroke. The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
2,593 studies on the registry are indexed under Ischemic Stroke; 930 are open to participants now.
This study's enrollment of 128 is close to the median of 120 across 1,752 interventional studies indexed under Ischemic Stroke.
Browse Ischemic Stroke studies →Yi Yang is the lead sponsor of 41 studies on the registry; 25 are open to participants now.
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Exclusion Criteria:
Patients are treated with repetitive transcranial magnetic stimulation (rTMS).
Procedure: Repetitive transcranial magnetic stimulation
Patients are treated with sham repetitive transcranial magnetic stimulation (sham-rTMS).
Procedure: Sham repetitive transcranial magnetic stimulation
After enrollment, patients received rTMS once a day for 5 consecutive days (stimulation plan: stimulation of M1 region on the affected side at 10Hz).
After enrollment, patients received sham-rTMS once a day for 5 consecutive days with the same parameters as the rTMS group, but the coil was rotated 90° away from the scalp.
phase difference(PD) in degree
A cerebral autoregulation parameter derived from transfer function analysis. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the cerebral autoregulatory parameter.
Time frame: 0-5 days
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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