An interventional study of prolonged SB and SB broken 1 in Type 2 Diabetes and Cardiovascular Diseases, sponsored by University of Minnesota. Completed at 1 site in United States. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2025-08-19.
Sponsored by University of Minnesota · Not applicable, Interventional, and Supportive care
Type 2 diabetes (T2D) confers a high risk of cardiovascular disease (CVD), particularly among older adults who tend to be physically inactive. Prolonged sedentary behavior (SB) has been shown to negatively influence markers of cardiovascular risk (e.g., blood glucose, blood pressure), even among individuals who are physically active. Most studies that have examined the effects of breaking up SB have focused on young healthy males and prioritized glycemic outcomes. Additionally, sex differences in these outcomes have not been adequately examined. The present study will address these gaps. This 3-arm crossover randomized controlled trial will compare the effects of 3 SB conditions on markers of vascular function. The 3 conditions are: 1) 4 hours of prolonged SB, 2) 4 hours of SB broken up by 5 minutes of self-paced walking every hour, and 3) 4 hours of SB with one 20-minute bout of self-paced walking. In addition to examining the overall effects of each condition, sex differences in physiological responses will be evaluated.
9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.
This study's enrollment of 34 is below the median of 80 across 7,525 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.
Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.
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Exclusion Criteria:
Control group
Behavioral: prolonged SB
Behavioral: SB broken 1
Behavioral: SB broken 2
4 hours of prolonged SB
4 hours of SB broken up by 5 minutes of self-paced walking every hour
4 hours of SB with one 20-minute bout of self-paced walking
iAUC of SBP
Net incremental area under the curve (iAUC) of systolic blood pressure (SBP)
Time frame: 90 days
Net iAUC of DBP
Net iAUC of diastolic blood pressure
Time frame: 90 days
Net iAUC of of MAP
Net iAUC of mean arterial pressure
Time frame: 90 days
Net iAUC of HR
Net iAUC of heart rate
Time frame: 90 days
This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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University of Minnesota