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CompletedNCT05832853Updated Apr 27, 2023

A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly

An interventional study of Wu Qin Xi exercise and Wu Qin Xi, resistance training and endurance training in Frail Elderly Syndrome, sponsored by Guang Yang, Prof. Dr.. Completed at 1 site in China. Open to participants aged 60 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-04-27.

Sponsored by Guang Yang, Prof. Dr. · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 4 years 10 months after the study started (first participant enrolled May 2018, registered Apr 2023).
Phase
Not applicable
Study type
Interventional
Enrollment
181
Allocation
Randomized
Ages
60 Years to 75 Years
Sex
All
01

Study summary

The declining physical condition of frail elderly is becoming an ugent problem. Although the exercise intensity of Wu Qin Xi appears to be low, it is highly effective in the older individuals. Inspired by the characteristics and functions of Wu Qin Xi, we designed a brand new exercise intervention training program among frail older people, which incorporates Wu Qin Xi, strength exercises and endurance exercises to improve physical fitness, and even reverse the condition of frailty. Furthermore, to improve utility in clinical practice, we innovatively employed machine learning simulations to infer the condition of older adults and predict their level of frailty after the intervention.

02

Conditions studied

  • Frail Elderly Syndrome

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Keywords

  • frailty
  • exercise intervention
03

In context

Frailty

1,229 studies on the registry are indexed under Frailty; 433 are open to participants now.

This study's enrollment of 181 is above the median of 80 across 704 interventional studies indexed under Frailty.

Browse Frailty studies →

Lead sponsor

This is the only study on the registry with Guang Yang, Prof. Dr. as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. a Fried frailty phenotype score of 3-5 points;
  2. could walk for at least 6 min without support;
  3. had not been able to walk in the past year other training.

Exclusion criteria

Exclusion Criteria:

  1. people who have a past mental illness or serious psychological issues which make it difficult to obey orders;
  2. people who have had neurological disorders within the last six months;
  3. people who must regularly participate in other training programs during the study period;
  4. people who struggle to walk normally due to significant muscle and skeletal injuries and continuous joint discomfort.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
181 participants (actual)

Study arms

  • Experimental
    Wu Qin Xi exercise

    The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group.

    Behavioral: Wu Qin Xi exercise

  • Experimental
    Wu Qin Xi, resistance training and endurance training

    The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of Wu Qin Xi exercise, resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

    Behavioral: Wu Qin Xi, resistance training and endurance training

  • Experimental
    Resistance training and endurance training

    The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.

    Behavioral: Resistance training and endurance training

Interventions

  • BehavioralWu Qin Xi exercise

    The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

  • BehavioralWu Qin Xi, resistance training and endurance training

    During the first 8 weeks, the training consists of learning and consolidating the movements of the Wu Qin Xi. In the second 16 weeks, participants perform a full set of movement exercises. Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and two sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 15 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

  • BehavioralResistance training and endurance training

    Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and three sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 30 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.

06

What researchers measure

Primary outcomes

  1. Assessing the endurance of frail older adults using the six-minute walk test

    Assessment of endurance in frail older adults before and after intervention using the six-minute walk test

    Time frame: Month 6

  2. Assessing the speed of frail older adults using the ten-meter maximum walk speed

    Assessment of speed in frail older adults before and after intervention using ten-meter maximum walk speed.

    Time frame: Month 6

  3. Using handgrip strength tests to assess strength in frail older adults.

    Using handgrip strength tests to assess strength in frail older adults before and after intervention

    Time frame: Month 6

  4. Assessment of balance in frail older adults using Time Up and Go Test.

    Assessment of balance in frail older adults before and after intervention using Time Up and Go Test.

    Time frame: Month 6

07

Study locations

1 site
  • Chinese Center of Exercise Epidemiology
    Changchun, Jilin 130024, China
08

References and documents

Publications

  • Wei M, He S, Meng D, Yang G, Wang Z. Hybrid Exercise Program Enhances Physical Fitness and Reverses Frailty in Older Adults: Insights and Predictions from Machine Learning. J Nutr Health Aging. 2023;27(10):894-902. doi: 10.1007/s12603-023-1991-0. PubMed 37960913 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from May 2018 to primary completion in Dec 2018, 7 months.

Of 477 non-industry interventional studies with no phase under Frailty, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 40. This study's 7 months is below that.

Counting every sponsor, half of 484 studies reached it within 21 months; a quarter within 9 and three quarters within 39.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 16, 2023
First posted
Apr 27, 2023
StartActual
May 20, 2018
Primary completionActual
Dec 30, 2018
CompletionActual
Jan 30, 2019
Last update
Apr 27, 2023
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 27, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05832853
Lead sponsor
Guang Yang, Prof. Dr.
Responsible party
Guang Yang, Prof. Dr. (Prof.Dr., Northeast Normal University) — Sponsor-investigator
First posted
Apr 27, 2023
Start date
May 20, 2018
Primary completion
Dec 30, 2018
Completion
Jan 30, 2019
Last update
Apr 27, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.

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