An interventional study of Apple and Mashed apple in Fructose Metabolism Disorder, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-20.
Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Basic science
Epidemiological evidence is accumulating that a high consumption of added sugars is associated with metabolic diseases such as non-alcoholic fatty liver disease and type 2 diabetes. Fructose, one of the principal added sugars, is believed to be the most disadvantageous sugar. Data from a large population-based cohort demonstrated that fructose intake from fruit juice and sugar-sweetened beverages, but not whole fruits, is associated with higher intrahepatic lipid content. A study in mice demonstrated that fast fructose exposure resulted in higher intrahepatic lipid content than slow fructose exposure.
The food matrix, i.e. the complex spatial organisation of and interactions between nutrients, may account for the fast versus slow fructose exposure and subsequent health consequences. Therefore the investigators aim to investigate the role of the fructose matrices on serum fructose peaks. The investigators hypothesize that liquid fructose matrices will cause higher serum fructose peaks in comparison to solid fructose matrices.
Objective: To quantify serum fructose peaks within 150 minutes following intake of fructose-containing matrices.
997 studies on the registry are indexed under Metabolic Diseases; 234 are open to participants now.
This study's enrollment of 23 is below the median of 48 across 670 interventional studies indexed under Metabolic Diseases.
Browse Metabolic Diseases studies →Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.
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Exclusion Criteria:
\[x\] gr apple containing 20 gr fructose as measured with an enzymatic method. Administered one time.
Other: Apple
\[x\] gr mashed apple containing 20 gr fructose as measured with an enzymatic method. Administered one time.
\[x\] ml apple juice containing 20 gr fructose as measured with an enzymatic method. Administered one time.
Other: Apple juice
20 gr of fructose powder dissolved in 300 ml of water. Administered one time.
Other: Fructose powder in water
20g fructose in \[x\] g of apple
20g fructose in \[x\] g of mashed apple
20g fructose in \[x\] ml apple juice
20g fructose in \[x\] ml water
Change in serum fructose between peak and baseline
Time frame: Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product.
Blood pressure
Millimeter of mercury
Time frame: Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product.
Serum uric acid
Millimoles per liter
Time frame: Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product.
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Maastricht University Medical Center