A Phase 1/2 interventional study of Allium Sativum Oil and Turmeric Gel in Non Vital Teeth, sponsored by University of Health Sciences Lahore. Completed at 1 site in Pakistan. Open to participants aged 4 Years to 8 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-19.
Sponsored by University of Health Sciences Lahore · Phase 1/2, Interventional, and Treatment
The purpose of the study is to use Allium sativum oil and Turmeric gel as non-vital Pulpotomy medicaments in primary teeth by evaluating their antibacterial effect against Streptococcus mutans and Lactobacillus acidophilus.
It is hypothesized that there is no difference in the antibacterial effect of Allium sativum oil and Turmeric gel when used as non-vital Pulpotomy medicaments.
It is a multi-arm parallel Randomized Controlled Trial in which forty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, will be selected and randomly divided into Group A (Allium sativum oil) and Group B (Turmeric gel). Non-vital Pulpotomy will be performed by removing the coronal necrotic pulp. Sterile paper point will be dipped in the root canals and taken to the laboratory. Cotton pellets soaked in the respective medicaments will be placed over the root canal orifices and filled temporarily. Patients will be recalled after one week. Samples will be again taken, and tooth restored. Comparison between bacterial count at baseline and after one week of treatment will be made and expressed as Colony-Forming Units/ml (CFU/ml).
University of Health Sciences Lahore is the lead sponsor of 80 studies on the registry; 50 are open to participants now.
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Premade Allium sativum oil (Garlic oil) (Mohammad and Baroudi, 2015b) will be used in this research (SAC group of companies-9001:2015 certified; Registration # PAK17.1724-U; NTN # 0299739-8, Karachi, Pakistan
Drug: Allium Sativum Oil
Turmeric gel will be self-prepared at the Institute of Microbiology and Molecular Genetics, Punjab University, Lahore. 2kgs of Turmeric rhizomes were purchased from a local market in Lahore and verified by a taxonomist, Botany Department, Government College University, Lahore (voucher number: GC.Herb.Bot.3693). Approximately 170g powder along with 550ml distilled water will be taken in a Soxhlet extractor for 96 hours and then filtered repeatedly through Whatman No.1 filter paper. The obtained filtrate will then be mixed with 6% Sodium Carboxy-Methyl Cellulose (NaCMC) (Genevex Chem, Hyderabad, India) to form gel. Four Vitamin C grounded tablets (Wilson's Vitamin C, Wilson's Healthcare, Islamabad, Pakistan) and twelve Vitamin E capsules (Evion, Martin Dow pharmaceuticals, Ltd. Karachi, Pak) will then be added in 100g of gel as antioxidants.
Drug: Turmeric Gel
Allium sativum oil will be used as non-vital pulpotomy medicament
Also known as: Medicaments for non-vital pulpotomy procedure
Drug pages: Turmeric extract · Curcuma longa
Turmeric gel will be used as non-vital pulpotomy medicament
Also known as: Medicaments for non-vital pulpotomy procedure
Antibacterial effect
Bacterial count of S. mutans and L. acidophilus counted as Colony Forming Units/ml (CFU/ml)
Time frame: 1 week
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Allyl sulfide · Turmeric extract · Curcuma longa
University of Health Sciences Lahore