An observational study in Bladder Cancer, sponsored by Jens Nielsen. Completed at 1 site in Sweden. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2023-04-05.
Sponsored by Jens Nielsen · Observational
Early detection of bladder cancer (BCa) is considered an effective strategy to curb mortality from the disease. However, current urinary biomarkers have insufficient specificity to warrant BCa screening. Urine free glycosaminoglycan profiles (or GAGomes) are promising noninvasive biomarkers of cancer metabolism. In this study, samples are obtained from patients with BCa and controls to compare the glycosaminoglycan profiles between groups.
716 studies on the registry are indexed under Carcinoma, Transitional Cell; 201 are open to participants now.
This study's enrollment of 106 is below the median of 200 across 123 observational studies indexed under Carcinoma, Transitional Cell.
Browse Carcinoma, Transitional Cell studies →Jens Nielsen is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Prospective case-control study to compare patients elected for transurethral resection of the bladder (TURB) for bladder cancer (BCa) [cases] versus patients with no evidence of disease (NED) during the follow-up of previously localised BCa [controls].
Cases (Bladder cancer [BCa])
Inclusion Criteria:
Exclusion Criteria:
Controls (No evidence of disease [NED])
Inclusion Criteria:
Exclusion Criteria:
Diagnostic Test: Free glycosaminoglycan profiling
Diagnostic Test: Free glycosaminoglycan profiling
Free glycosaminoglycan profiling (GAGome) analysis was performed at a single blinded central laboratory using commercial kits wherein the concentration (in µg/mL) of 17 chondroitin sulfate (CS), heparan sulfate (HS), hyaluronic acid (HA) disaccharides were detected and quantified using a UHPLC-MS/MS system.
Area-under-the-receiving operating characteristic (ROC)-curve (AUC) for the classification of BCa versus NED
Time frame: Before primary surgery for BCa; at a post-surgical follow-up visit for controls up to 5 years from primary surgery
Plan to share: No
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This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Jens Nielsen