An observational study in COVID-19, Cognitive Decline and Otological Disease, sponsored by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2023-03-28.
Sponsored by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Observational
The purpose of this study was to analysis the incidence of ear symptoms, cognitive function decline and emotional disorders in Chinese people who were infected with COVID-19, exploring the impact of COVID-19 on the auditory system, cognitive function and emotional function, and analyzing the changes in functional connectivity of brain network after COVID-19 infection.
7,990 studies on the registry are indexed under COVID-19; 466 are open to participants now.
This study's enrollment of 30 is below the median of 268 across 3,208 observational studies indexed under COVID-19.
Browse COVID-19 studies →Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University is the lead sponsor of 483 studies on the registry; 283 are open to participants now.
Counted across the registry records on this site, refreshed daily.
A total of 748 patients with novel coronavirus were surveyed from December 2022 to February 2023.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with hearing loss after infection
Patients with hearing loss before infection
Healthy subjects who have never been infected with COVID-19 or diagnosed with hearing loss.
The correlation between the peak of COVID-19 transmission and the popularity of related online terms
The correlation between the peak of COVID-19 transmission and the popularity of related online terms
Time frame: through study completion, an average of 3 months
Symptom incidence
According to the questionnaire survey of 748 patients, the incidence of hearing loss, tinnitus, ear tightness, earache, vertigo or other cognitive and emotional problems after COVID-19 was analyzed.
Time frame: through study completion, an average of 3 months
Pure tone average
According to the WHO grading standard of hearing loss in 1980, the average pure tone threshold (PTA) of 0.5k, 1k, 2k and 4kHz in better ears was defined as normal hearing, 26-40 dB HL(hearing level) was defined as mild hearing loss, and 41-55 dB HL was defined as moderate hearing loss. 56-70 dB HL was moderate to severe hearing loss, 71-90 dB HL was severe hearing loss, and ≥91 dB HL was extremely severe hearing loss.
Time frame: through study completion, an average of 3 months
Mini-Mental State Examination score and grade
There are 30 points in the Mini-Mental State Examination (MMSE) scale. The score of 27-30 is normal, and 21-26 is mild dementia. 10-20 is moderate dementia; On a scale of 0 to 9, dementia is severe
Time frame: through study completion, an average of 3 months
Montreal Cognitive Assessment score and grade
The total score of the Montreal Cognitive Assessment (MoCA) scale is 30 points, generally ≥26 points normal, 18-26 points mild cognitive impairment, 10-17 points moderate cognitive impairment, and \< 10 points severe cognitive impairment.
Time frame: through study completion, an average of 3 months
Pittsburgh Sleep Quality Interview score and grade
Pittsburgh Sleep Quality Index (PSQI) Scale total scores 21 points. A score of 0-5 indicates good sleep quality; A score of 6-10 indicates good sleep quality; 11-15 points, indicating average sleep quality; A score of 16 to 21 indicates poor sleep quality
Time frame: through study completion, an average of 3 months
Hamilton depression score and grade
For the 24th version of Hamilton depression Scale (HAMD), the total score \> 35 May indicate severe depression; 21-35, may be mild to moderate depression; 9-20, suspected depression; \< 8 indicates normal.
Time frame: through study completion, an average of 3 months
Resting state of Electroencephalogram data
Electroencephalogram (EEG) data of the study were preprocessed and trends in functional brain network connectivity were analyzed.
Time frame: through study completion, an average of 3 months
This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University →