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CompletedNCT05771350Updated Mar 16, 2023

Online Hemodiafiltration Versus Hemodialysis in Removal of Indoxyl Sulfate in Chronic Hemodialysis Patients

An interventional study of online hemodiafiltration and high flux hemodialysis in Hemodialysis, sponsored by Ain Shams University. Completed. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-03-16.

Sponsored by Ain Shams University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 6 years 3 months after the study started (first participant enrolled Nov 2016, registered Mar 2023).
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
All
01

Study summary

this study aimed to compare the removal of indoxyl sulphate between hemodiafiltration, high flux hemodialysis and low flux hemodialysis

02

Conditions studied

  • Hemodialysis
03

In context

Lead sponsor

Ain Shams University is the lead sponsor of 1,876 studies on the registry; 423 are open to participants now.

Of its 32 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • maintenance hemodialysis patients aged more than 18 years

Exclusion criteria

Exclusion Criteria:

  • active illnesses, hospitalization, malignancy
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    online hemodiafiltration

    Procedure: online hemodiafiltration

  • Active comparator
    high flux hemodialysis

    Procedure: high flux hemodialysis

  • Active comparator
    low flux hemodialysis

    Procedure: low flux hemodialysis

Interventions

  • Procedureonline hemodiafiltration

    20 patients on regular hemodialysis received online hemodiafiltration

  • Procedurehigh flux hemodialysis

    20 patients on regular hemodialysis received high flux hemodialysis

  • Procedurelow flux hemodialysis

    20 patients on regular hemodialysis received low flux hemodialysis

06

What researchers measure

Primary outcomes

  1. dialytic removal of indoxyl sulpahte

    assessed by the reduction ration of indoxyl sulphate

    Time frame: one month when all samples were collected

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 16, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05771350
Lead sponsor
Ain Shams University
Responsible party
Mohamed sary gharib (Dr, Ain Shams University) — Principal investigator
First posted
Mar 16, 2023
Start date
Nov 15, 2016
Primary completion
Jan 15, 2017
Completion
Jan 15, 2017
Last update
Mar 16, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.

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