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Not yet recruitingNCT05745506Updated Feb 27, 2023

Effect of Sleep Disorder on the Development of Lung Tumors

An observational study in Sleep Disorder, Lung Tumor, sponsored by RenJi Hospital. Not yet recruiting. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-02-27.

Sponsored by RenJi Hospital · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2026, 4 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
18 Years to 75 Years
Sex
All
01

Study summary

The goal of this observational study is to observe the lung tumor development in lung tumor patients with long-term sleep disorder. The main questions it aims to answer are:

  • will long-term sleep disorder promote the malignancy of lung tumor
  • if so, how exactly will the microenvironment of lung tumor change Participants will receive PSQI scale and MRI functional brain imaging before surgery, blood and tumor tissue will be collected during the surgery.

Researchers will set non-sleep disorder group as control group to see if lung tumor microenvironment change when long-term sleep disorder exists in lung tumor patiens.

02

Conditions studied

  • Sleep Disorder, Lung Tumor
03

In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,558 are open to participants now.

This study's planned enrollment of 200 is close to the median of 189 across 1,512 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Participants are 18-75 years old man or women diagnosed with primary lung tumor.

Inclusion criteria

  • 18-75 years old
  • elective sublobectomy for primary lung tumor
  • ASA grade I-II
  • Informed consent of the patient or family

Exclusion criteria

Exclusion Criteria:

  • Combination of serious heart, liver, kidney, central nervous system, blood system, immune system diseases or serious mental illness
  • Combination of other cancers
  • untreated active lung infection
  • patients with preoperative neoadjuvant radiotherapy
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • CRD

    patients whose PSQI score\>5

  • non-CRD

    patients whose PSQI score ≦ 5

06

What researchers measure

Primary outcomes

  1. tumor microenvironment in sleep-disordered lung cancer patients

    we use single cell sequencing to analyze microenvironment alterations of tumor tissues in enrolled patients.

    Time frame: 3 months after surgery

Secondary outcomes

  1. peripheral blood levels of neurotransmitters in sleep-disordered lung cancer patients

    peripheral blood levels of epinephrine, noradrenaline, 5-HT in sleep-disordered lung cancer patients

    Time frame: 3 months after surgery

  2. Functional brain imaging in sleep-disordered lung cancer patients

    Functional brain imaging

    Time frame: 3 months after surgery

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 27, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05745506
Lead sponsor
RenJi Hospital
Responsible party
Sponsor
First posted
Feb 27, 2023
Start date
Feb 2023 (estimated)
Primary completion
Jun 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Feb 27, 2023

Study contacts

Weifeng Yu
Contact
ywf808@yeah.net
13901961704
Yumiao Shi
Contact
shiyumiaoxka@163.com
19821850236
Weifeng Yu
study director · Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.

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