An interventional study of high-dose accelerated intermittent theta burst stimulation and sham high-dose accelerated intermittent theta burst stimulation in Alcohol Dependence, sponsored by Berthold Langguth, MD, Ph.D.. Recruiting at 1 site in Germany. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-09-19.
Sponsored by Berthold Langguth, MD, Ph.D. · Not applicable, Interventional, and Treatment
This is a two-arm randomized placebo-controlled trial in which 72 patients with alcohol addiction are treated with high-dose accelerated intermittent theta burst stimulation (TBS).
1,606 studies on the registry are indexed under Alcoholism; 329 are open to participants now.
This study's planned enrollment of 72 is below the median of 87 across 1,371 interventional studies indexed under Alcoholism.
Browse Alcoholism studies →Berthold Langguth, MD, Ph.D. is the lead sponsor of 3 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold
Device: high-dose accelerated intermittent theta burst stimulation
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold with angled coil
Device: sham high-dose accelerated intermittent theta burst stimulation
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold
1200 pulses of iTBS per session with five sessions per day applied at five days (Monday-Friday) with 120% resting motor threshold with angled coil
Craving visual analoge scale
alcohol craving according to visual analog scale (range: 0-100; higher values = worse outcome)
Time frame: one week
Craving visual analoge scale
alcohol craving according to visual analog scale (range: 0-100; higher values = worse outcome)
Time frame: 13 weeks
relapse (number of patients with alcohol relapse)
number of patients with alcohol relapse
Time frame: 13 weeks
heavy drinking days
number of heavy drinking days (four drinks for female and five drinks for male)
Time frame: 13 weeks
abstinence confidence
abstinence confidence (Kurzfragebogen zur Abstinenzzuversicht KAZ-35; only available in German; range: 0-100%; higher values = worse outcome)
Time frame: 13 weeks
degree of dependence
degree of dependence according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) (range: mild, moderate, severe)
Time frame: 13 weeks
Fagerström Test for Nicotine Dependence
Fagerström Test for Nicotine Dependence (range: 0-10; higher values = worse outcome)
Time frame: 13 weeks
major depression inventory
Major Depression Inventory (range: 0-50; higher values = worse outcome)
Time frame: 13 weeks
World Health Organisation quality of life bref
World Health Organisation quality of life bref (range: 4-20; lower values = worse outcome)
Time frame: 13 weeks
Plan to share: No
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Berthold Langguth, MD, Ph.D.