An observational study in Twin Pregnancy, sponsored by Fudan University. Recruiting at 1 site in China. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-14.
Sponsored by Fudan University · Observational
Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.
Data are collected regarding the pregnancy data of the mother, and mental, physical and sociodemographic information of the offspring. The periods span from diagnosis of twins to 3 years old of the offspring. Biological samples would be collected including maternal blood, placental tissues, cord blood, urine, and stool from the pregnant women or the offspring at the specific time.
The total estimated duration of the study is 6 years, of which the first 2.5 years will correspond to the recruitment period of the participants.
Fudan University is the lead sponsor of 1,270 studies on the registry; 623 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Woman with twin pregnancy and their offspring within 3 years old.
Exclusion Criteria:
Other: All pregnant women with a twin pregnancy and the offspring
No intervention
Also known as: No intervention
The incidence of maternal and fetal complications
The incidence of preeclampsia, gestational diabetes mellitus, premature delivery, postpartum hemorrhage, twin to twin transfusion syndrome, selective intrauterine growth restriction.
Time frame: From confirmation of pregnancy to 42 days postpartum
RNA profiles in placentas of twin pregnancy measured by RNA-sequencing
Levels of placental RNA expression.
Time frame: Immediately after delivery
Global DNA methylation in placentas of twin pregnancy measured by whole-genome bisulfite sequencing
Global DNA methylation levels in placentas of twin pregnancy.
Time frame: Immediately after delivery
Protein profiles in placentas of twin pregnancy measured by tandem mass tags quantification.
Levels of proteins in placentas of twin pregnancy.
Time frame: Immediately after delivery
Post-translation modification of proteins in placentas of twin pregnancy measured by Integrative use of phosphoproteomics, ubiquitylproteomics and acetylproteomics.
Post-translational levels of proteins in placentas of twin pregnancy.
Time frame: Immediately after delivery
Metabolite profiles in placentas of twin pregnancy measured by metabolomics
Metabolite profiles in placentas of twin pregnancy.
Time frame: Immediately after delivery
Lipid profiles in placentas of twin pregnancy measured by lipidomic analysis
Lipid profiles in placentas of twin pregnancy.
Time frame: Immediately after delivery
Predictive protein markers of maternal and fetal complications in maternal blood measured by tandem mass tags quantification
Levels of specific proteins in maternal blood.
Time frame: From confirmation of pregnancy to 42 days postpartum
Predictive RNA markers of maternal and fetal complications in maternal blood measured by RNA-sequencing
Levels of specific RNAs in maternal blood.
Time frame: From confirmation of pregnancy to 42 days postpartum
Predictive metabolite markers of maternal and fetal complications in maternal blood measured by metabolomics
Levels of specific metabolites in maternal blood.
Time frame: From confirmation of pregnancy to 42 days postpartum
Predictive lipid markers of maternal and fetal complications in maternal blood measured by lipidomic analysis
Levels of specific lipids in maternal blood.
Time frame: From confirmation of pregnancy to 42 days postpartum
The level of twin Neurodevelopment assessed by Gesell Developmental Schedules
The parameters in Gesell Developmental Schedules including adaptive, gross motor, fine motor, language, and social function.
Time frame: Age at 3 years of the offspring
The incidence of long term maternal complications
Including hypertension, diabetes mellitus and metabolic disease.
Time frame: Three years after delivery
Plan to share: No
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Fudan University