An interventional study of Community mobilization and Conditional community incentives in Polio, Immunization; Infection and Incentives, sponsored by Aga Khan University. Completed at 1 site in Pakistan. Open to participants aged 1 Day to 59 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-26.
Sponsored by Aga Khan University · Not applicable, Interventional, and Prevention
Immunization is one of the most cost-effective and successful public health strategy in reducing the health, economic and societal burden of many infectious diseases. Pakistan and Afghanistan remain the only countries where polio is endemic, and Pakistan reports the most cases in the world. Although the rate is lower than in previous years, the situation remains alarming. This study objective is to decrease polio vaccine refusals and zero-dose vaccines by motivating behaviour change
Study Design:The study will adopt a pretest/post-test quasi-experimental approach with two intervention UCs and two control UCs. For each target, intervention SHRUC, a separate, matched control SHRUC of comparable size and location will be identified for eventual pre-post comparison. Children under-five will be eligible for inclusion.
Intervention: The intervention package will include community mobilization and incentivization. Clusters will be formed on a population of 2000-2500 in each intervention UC, thus approximately ten clusters in each. Project will form or liaise with community groups or committees (male and female) in each cluster, which are already operational in many parts of the target UCs. However, to focus on reducing polio vaccine refusals, our program will adopt a unique incentivization approach, preceded by trust-building community mobilization. Clusters will be determined based on the existing micro plans of the PPEP. Microplans are a population-based set of components, at UC-level, used by the program for delivering polio vaccination efficiently. Baseline and end-line surveys will be conducted in the target and control UCs.
Study Site: The study will be conduucted in district Karachi, Sindh and other in district Bannu, KP.
Intervention UCs: Haji Mureed Goth Karchi and Mira-Khel KP COntrol UCs : Nazivmabad UC 49 Karachi and Khwajamad- Bannu)
The research team will engage with multiple village/mohalla committees in the intervention UCs to address and eliminate misconceptions about polio. One-to-one meetings and group sessions which will be led by the committee members, to provide messages on childhood immunization with project-specific IEC material, will be held in each targeted cluster. These platforms would be helpful to identify and counsel their underlying fears and socio-psychological factors about the vaccines, such as painful neonatal experiences, mishandling, doubts, fear of vaccine-related side effects, distrust, etc.
The community-based incentives will be conditional based on the decrease in vaccine refusal rates within stipulated time. Communities successful in achieving these targets will be rewarded incentives to improve their infrastructure, including sanitation and hygiene, and water resources.
274 studies on the registry are indexed under Poliomyelitis; 18 are open to participants now.
This study's enrollment of 840 is above the median of 476 across 249 interventional studies indexed under Poliomyelitis.
Browse Poliomyelitis studies →Aga Khan University is the lead sponsor of 294 studies on the registry; 43 are open to participants now.
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The study will adopt a pretest/post-test quasi-experimental design. The approach of the proposed project is to implement a participatory community engagement and demand creation strategy with trust-building community mobilization and a conditional community-based incentive scheme to reduce the refusals to vaccination and improve polio immunization coverage in intervention UCs. Clusters will be formed on a population of 1500-2000 in each intervention UC. Committees would be formed with approximately 5-7 prominent members of the community. Intervention Non-cash, incentives would be given and decided with consensus by UC committees and aim to improve infrastructure linked to health including water and sanitation and toilets in the community.
Behavioral: Community mobilization and Conditional community incentives
This would be the standard of care
Non-cash, incentives would be given to clusters which improve the polio vaccine coverage and reduce the refusals and these incentives would be decided with consensus by community and costs would be shared
Vaccine refusals
Number of polio vaccine refusals in polio campaign
Time frame: at 9 months
Fully Immunized Children
This would be children who are fully vaccinated appropriate to the age
Time frame: at 9 months
IPV coverage
this would be injectable polio vaccine coverage in children below five years of age
Time frame: at 9 months
Ran from Dec 2022 to primary completion in Mar 2024, 15 months.
Of 16 interventional studies with no phase under Poliomyelitis, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 22. This study's 15 months is below that.
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This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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