An interventional study of Vitamin D in Osteomalacia, sponsored by TUĞBA ŞAHBAZ. Status unknown. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2023-02-14.
Sponsored by TUĞBA ŞAHBAZ · Not applicable, Interventional, and Treatment
Evaluation of the change of serum Prolidase and Leptin values in the diagnosis and follow-up of osteomalacia and its clinical usability
Osteomalacia describes a bone disorder in adults that is usually caused by long-term vitamin D deficiency. Osteomalacia, a metabolic bone disease characterized by impaired mineralization of the bone matrix.Not a single laboratory finding is specific to osteomalacia.The relationship between collagen and prolidase activity has been observed during fibrotic processes, where an increase in prolidase activity is accompanied by an increase in tissue collagen deposition. It has also been suggested that serum activity is increased in metabolic bone diseases.Leptin is a 16 kDa peptide hormone. It is a member of the long chain helical cytokine family, which is mainly produced by fat cells and proportional to the size of the stored fat. Leptin affects bone remodeling by reducing the activity of osteoclasts and thus participates in the pathogenesis of osteoporosis. In the light of these studies, the investigators planned our study according to the clinical significance of serum prolidase activity in osteomalacia and the place of leptin in osteomalacia.
34 studies on the registry are indexed under Osteomalacia; 3 are open to participants now.
This study's planned enrollment of 38 is above the median of 15 across 17 interventional studies indexed under Osteomalacia.
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Our study, which is the only group planned prospectively, aims to compare clinical and laboratory data and serum prolidase activity and leptin levels in 38 patients diagnosed with osteomalacia after and before 8 weeks of 50,000 IU D vit treatment.
Dietary Supplement: Vitamin D
50,000 IU vit D treatment for 8 weeks
Also known as: vit D treatment
Serum Prolidase activity
Prolidase activity
Time frame: 8 weeks
Serum Leptin
Leptin
Time frame: 8 weeks
No study locations are listed for this record.
Plan to share: No
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This study is status unknown, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Vitamin D