An interventional study of Sugar in Sucrase-Isomaltase Deficiency and Irritable Bowel Syndrome, sponsored by Region Skane. Completed at 1 site in Sweden. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-06-27.
Sponsored by Region Skane · Not applicable, Interventional, and Diagnostic
The investigators know that many patients with irritable bowel syndrome (IBS) have functional variants of genes coding for sucrase-isomaltase enzymes. The investigators will now examine whether these functional variants are associated with defect degradation of sucrose and associated gastrointestinal symptoms
The investigators have in a previous study included IBS patients for treatment with a starch- and sucrose reduced diet (SSRD). The investigators found a great improvement of symptoms. The investigators gene-tested those patients, and now have the full identification of all functional variants encoding sucrase-isomaltase enzymes.
The investigators will invite patients from this previous study with normal genes and functional variants of genes. The patients will come fasting over night to the department of clinical research. The participants will ingest 75 g sugar dissolved in 0.8 dl water and flavored with lemon, to ingest during 5 minutes. After that, glucose will determined repeatedly up to 2 hours afterwards. At the same time, the participants have to assess their gastrointestinal sympotms on visual analogue scales (VAS).
The investigators will compare the raise in b-glucose and symptoms between the groups of patients, divided into gene expression.
1,062 studies on the registry are indexed under Irritable Bowel Syndrome; 190 are open to participants now.
This study's enrollment of 40 is below the median of 71 across 853 interventional studies indexed under Irritable Bowel Syndrome.
Browse Irritable Bowel Syndrome studies →Region Skane is the lead sponsor of 372 studies on the registry; 113 are open to participants now.
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Exclusion Criteria:
Sugar dissolved in water will be ingested during 5 minutes
Dietary Supplement: Sugar
75 g sugar dissolved in 0.8 dl water and flavored with lemon. Ingested during 5 minutes
Changes from baseline of blood glucose levels
Measurement of glucose levels in blood drawn from an intravenous needle and analyzed at the Department of Clinical Chemostry
Time frame: From distribution repeatedly up to 2 hours
Change from baseline of gastrointestinal symptoms
Measurment of gastrointestinal symptoms on a visual analog scale measuring symptoms, range 0-100 mm, repeatedly at the same time points as blood glucose is measured. The higher scores, the worse symptoms.
Time frame: From baseline and up to 2 hours, at the same time points as blood glucose is measured
Plan to share: No
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This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Sucrase-isomaltase deficiency, congenital
Region Skane