CClinicalTrials.gg
Status unknownNCT05678777Updated Jan 10, 2023

Use of Galvanic Skin Response to Measure Peripheral Block Activity

An observational study in Regional Anesthesia, sponsored by Adiyaman University. Status unknown at 1 site in Turkey. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-10.

Sponsored by Adiyaman University · Observational

The sponsor has not verified this record recently (last verified Jan 2023), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
50
Ages
18 Years to 65 Years
Sex
All
01

Study summary

the investigators aim in this study is to determine whether the block is successful in successful infraclavicular brachial plexus blocks performed with USG, according to the change in GSR value in the upper extremity blocked due to sympathetic nerve blockade. Block success will be evaluated by sensory and motor examination of the blocked arm.

Read the detailed description

Peripheral nerve block is one of the commonly used blocks in regional anesthesia. In regional anesthesia applications, there are important advantages such as being conscious of the patient, expressing his complaints, continuation of spontaneous breathing, preservation of airway reflexes, continuation of analgesia in the postoperative period and early mobilization of the patient.

In 1978, ultrasound (USG) was used for the first time in peripheral nerve block. With USG, it is possible to monitor the nerves and anatomical structures, follow the needle, and reduce the dose by monitoring the distribution of the local anesthetic administered. Therefore, USG-guided peripheral nerve blocks are frequently used in anesthesia practice.

The Galvanic Skin Response (GSR) is a simple way to obtain autonomic nervous system dependent sweat gland function as a parameter.

Physically, the galvanic skin response is the change in the electrical structure of the skin to various stimuli. Changes in tension measured from the skin surface are recorded. The galvanic skin response is a useful, simple and reproducible electrophysiological technique for investigating sympathetic nervous system function.

The relaxation, calming response that accompanies an increase in skin resistance (causing a decrease in GSR meter) is the body's combat response that accompanies a decrease in skin resistance (causing an increase in GSR meter). Generally, low conductivity is a sign of relaxation. High conductivity is a sign of emotional, mental, or physical arousal. The galvanic skin response is a simple way to obtain autonomic nervous system-related sweat gland function as a parameter.

the investigators aim in this study is to determine whether the block is successful in successful infraclavicular brachial plexus blocks performed with USG, according to the change in GSR value in the upper extremity blocked due to sympathetic nerve blockade. Block success will be evaluated by sensory and motor examination of the blocked arm. The relaxation, calming response that accompanies an increase in skin resistance (causing a decrease in GSR meter) is the body's combat response that accompanies a decrease in skin resistance (causing an increase in GSR meter). Generally, low conductivity is a sign of relaxation. High conductivity is a sign of emotional, mental, or physical arousal.

In the investigators clinic, peripheral nerve blocks accompanied by USG are frequently used in anesthesia practice.

OBJECTİVE: Successful peripheral nerve blockade results in local vasodilation, increased local blood flow, and some increase in skin temperature due to sympathetic fiber blocking. However, in busy operating room conditions, these clinical signs may not appear quickly enough to confirm block adequacy, especially before or during surgery, and may not be used for clinical decision making. Traditional methods for assessing block success are time consuming and require patient cooperation. For the success of the block, it is aimed to use the Galvanic Skin Response (GSR) value, which is a non-invasive method that does not require patient cooperation and provides rapid evaluation.

Galvanic Skin Response (GSR) measurement is a non-invasive and rapid assessment that allows us to observe the skin resistance change with two probes attached to the fingertip. In the investigators study, we aimed to show that the Galvanic Skin Response (GSR) measurement method is a reliable and objective method to evaluate the adequacy of peripheral nerve blocks.

METHODS: This research; It is a prospective observational study. In patients who have performed infraclavicular brachial plexus block; The correlation of Galvanic skin response (GSR) values measured with the finger probe that we attached to the patient's two fingers before and after the block, with the success of the block will be examined. the investigators study is not invasive, it is only in the form of examining finger probe measurements and will not create an additional cost for the investigators hospital and the participants..

02

Conditions studied

  • Regional Anesthesia

Keywords

  • Galvanic Skin Response
  • Peripheral Block
03

In context

Lead sponsor

Adiyaman University is the lead sponsor of 28 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

patients aged 18-65 who will undergo upper extremity surgery

Inclusion criteria

  1. ASA1-ASA2 patients
  2. Patients between the ages of 18-65
  3. Patients who underwent infraclavicular block

Exclusion criteria

Exclusion Criteria:

  1. ASA3-ASA4 patients
  2. Patients younger than 18 years old and over 65 years old
  3. Patients who do not want to be included in the study
  4. Patients in whom infraclavicular brachial plexus block is contraindicated
  5. Patients who cannot cooperate
  6. Those with diabetes mellitus
  7. Patients who have failed infraclavicular brachial plexus block and switched to general anesthesia
  8. Those with peripheral artery disease
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • DeviceGalvanic Skin Response

    The probe will be attached to the patient's finger and the Galvanic Skin Response will be measured

06

What researchers measure

Primary outcomes

  1. Galvanic Skin Response

    Time frame: 30/01/2023-28/02/2023

07

Study locations

1 of 1 sites recruiting
  • Adiyaman University
    Adıyaman, 32000, Turkey
    Recruiting
08

References and documents

Publications

  • Tarvainen MP, Koistinen AS, Valkonen-Korhonen M, Partanen J, Karjalainen PA. Analysis of galvanic skin responses with principal components and clustering techniques. IEEE Trans Biomed Eng. 2001 Oct;48(10):1071-9. doi: 10.1109/10.951509. PubMed 11585030 ↗
  • Marhofer P, Greher M, Kapral S. Ultrasound guidance in regional anaesthesia. Br J Anaesth. 2005 Jan;94(1):7-17. doi: 10.1093/bja/aei002. Epub 2004 Jul 26. PubMed 15277302 ↗

Individual participant data

Plan to share: Undecided — ı am undecided about sharing individual participant data with other researchers

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 10, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05678777
Lead sponsor
Adiyaman University
Responsible party
Fikret Ozerdem (assistant doctor, Adiyaman University) — Principal investigator
First posted
Jan 10, 2023
Start date
Jan 30, 2022
Primary completion
Feb 28, 2023 (estimated)
Completion
Mar 30, 2023 (estimated)
Last update
Jan 10, 2023

Study contacts

Öznur Uludağ
Contact
uludagoznur@gmail.com
05052309730 ext. 04162231690

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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