An interventional study of Point-of-care ultrasound-driven diagnostic pathway in Dyspnea, sponsored by Aarhus University Hospital. Completed at 9 sites in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-10-01.
Sponsored by Aarhus University Hospital · Not applicable, Interventional, and Diagnostic
The POCUS PATHWAY-trial is a multi-center, randomized, investigator-initiated, open labelled, pragmatic, controlled trial of a point-of-care ultrasound-driven diagnostic pathway vs standard diagnostic pathway in dyspneic emergency department patients. The primary outcome will be 24-hour hospital stay and 642 patients will be included. Key secondary outcomes include overall hospital length of stay, image resources, and 72-hour revisits.
656 studies on the registry are indexed under Dyspnea; 153 are open to participants now.
This study's enrollment of 674 is above the median of 48 across 430 interventional studies indexed under Dyspnea.
Browse Dyspnea studies →Aarhus University Hospital is the lead sponsor of 289 studies on the registry; 79 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The intervention is focused lung and cardiac ultrasound performed as an extension to physical examinations plus diagnostic decision recommendations based on those test results (a point-of-care ultrasound-driven diagnostic pathway). Final decision on next-line imaging and further diagnostic testing should incorporate history and other physical examinations and will remain upon the treating physicians' discretion.
Diagnostic Test: Point-of-care ultrasound-driven diagnostic pathway
Standard diagnostic pathway will include, but not be limited to, blood samples, blood gases, electrocardiogram, and chest x-ray. Focused lung and cardiac ultrasound cannot be performed while the patients stay in the emergency department.
Focused lung ultrasound will include 8 zones (anterior and lateral) and evaluate pneumothorax, interstitial syndrome, lung consolidation, and pleural effusion. Focused cardiac ultrasound will include four views (subxiphoid four-chamber view, parasternal long-axis view, parasternal short-axis view, and apical four-chamber view) and evaluate pericardial fluid, right ventricle dilation, and left ventricular systolic contractility.
24-hour hospital stay
Proportion of patients with a hospital lenght-of-stay of less than 24 hours.
Time frame: From date of hospital admission until the date of first documented hospital discharge, assessed up to 24 hours.
Hospital length-of-stay
Hospital length-of-stay will secondarily be analyzed using time-to-event analysis.
Time frame: From date of hospital admission until the date of first documented hospital discharge, assessed up to 3 months.
Image resources
Image resources will be presented as a composite absolute number and incidence proportion counting the cumulative number of participants having received any of the following imaging techniques during the current hospital stay: chest x-rays, echocardiography, computed tomography (CT) angiography, and CT thorax.
Time frame: From date of hospital admission until the date of first documented hospital discharge, assessed up to 3 months.
Number of participants with the composite outcome of 72-hour revisits and overall mortality
72-hour revisits will be defined as a composite outcome including any unplanned hospital stay within 72 hours from the previous hospital discharge, in-hospital mortality, and mortality within 72 hours from the previous hospital discharge.
Time frame: From date of hospital admission until 72 hours after the date of first documented hospital discharge, assessed up to 3 months.
Plan to share: Yes — Six months after the publication of the last results, all de-identified individual patient data will be made available for data sharing.
Supporting information: Study protocol, Sap, Analytic code
This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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Aarhus University Hospital