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CompletedNCT05673395Updated Jan 17, 2023

Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise

An interventional study of Electrolyzed alkaline reduced water generator in Oxidative Stress, sponsored by Kyu Jae Lee. Completed at 1 site in Korea, Republic of. Open to participants aged 19 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-17.

Sponsored by Kyu Jae Lee · Not applicable, Interventional, and Screening

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Jun 2022, registered Dec 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
19 Years to 25 Years
Sex
All
01

Study summary

The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. The main question[s] it aims to answer are:

  • [question 1] Can pH 9.5 EARW reduce oxidative stress compared to purified water (PW)
  • [question 2] Can pH 9.5 EARW decrease fatigue markers in blood

Participants will drink water from the experimental device after high-intensity exercise. Blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water.

Researchers will compare EARW group and PW group to see the anti-oxidative and anti-fatigue effects.

Read the detailed description

This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after highly intense exercise.

The participants were divided into two groups, wherein they consumed either purified water (PW group) or EARW (EARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water.

For the anti-oxidative effect, ROS, NO, GPx, and MDA levels were measured. For the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.

02

Conditions studied

  • Oxidative Stress

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03

In context

Fatigue

1,860 studies on the registry are indexed under Fatigue; 376 are open to participants now.

This study's enrollment of 24 is below the median of 54 across 1,440 interventional studies indexed under Fatigue.

Browse Fatigue studies →

Lead sponsor

Kyu Jae Lee is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy male participants aged 19-25 years
  • physically active with a normal body mass index (BMI)
  • had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study.

Exclusion criteria

Exclusion Criteria:

  • any kind of visible or known disease
  • hypertension,
  • musculoskeletal injuries in the previous three months,
  • breathing difficulties,
  • metabolic diseases,
  • autoimmune disease,
  • rash,
  • urticaria.
05

Study design

Phase
Not applicable
Primary purpose
Screening
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
24 participants (actual)

Study arms

  • Experimental
    EARW group

    This group drink electrolyzed alkaline reduced water (EARW, pH 9.5) 10 mL/kg body weight in 10 min after exercise.

    Device: Electrolyzed alkaline reduced water generator

  • Sham comparator
    PW group

    PW is purified water generated from sham device, and PW group drink 10 mL/kg body weight in 10 min after exercise.

    Device: Electrolyzed alkaline reduced water generator

Interventions

  • DeviceElectrolyzed alkaline reduced water generator

    Participants drink water (10 mL/kg body weight) generated from the device after intensive excercise.

    Also known as: Electrolyzed alkaline ionizer (CGM MWPI-2101

06

What researchers measure

Primary outcomes

  1. EARW consumption is effective in reducing oxidative stress

    Reactive oxygen species, nitric oxide, glutathione peroxidase, malondialdehyde

    Time frame: 15 minutes

Secondary outcomes

  1. The effects of EARW consumption on exercise-induced fatigue markers in healthy young adults

    Lactate levels, phosphate levels, cytokines

    Time frame: 15 minutes

07

Study locations

1 site
  • Wonju Severance Christian Hospital
    Wonju, Ganwon-do 26426, Korea, Republic of
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 17, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05673395
Lead sponsor
Kyu Jae Lee
Collaborators
Ceragem Inc.
Responsible party
Kyu Jae Lee (Professor, Wonju Severance Christian Hospital) — Sponsor-investigator
First posted
Jan 6, 2023
Start date
Jun 13, 2022
Primary completion
Jun 30, 2022
Completion
Jun 30, 2022
Last update
Jan 17, 2023

Study contacts

Kyu-Jae Lee, Ph.D.
study chair · 20, Ilsan-dong, Wonju, Gangwon-do, South Korea, 26426

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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