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CompletedNCT05662254PERMAUpdated Mar 27, 2025

PERsonalized Mood Augmentation Trial for Depressed Mood

An interventional study of Personalized Behavioral Intervention in Depression, sponsored by University of California, San Diego. Completed at 1 site in United States. Open to participants aged 15 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-27.

Sponsored by University of California, San Diego · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Jun 2022, registered Dec 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Not applicable
Ages
15 Years and older
Sex
All
01

Study summary

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.

Read the detailed description

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.

02

Conditions studied

  • Depression

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03

In context

Depression

8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.

This study's enrollment of 40 is below the median of 84 across 6,720 interventional studies indexed under Depression.

Browse Depression studies →

Lead sponsor

University of California, San Diego is the lead sponsor of 958 studies on the registry; 191 are open to participants now.

Of its 110 completed or terminated interventional studies of FDA-regulated products, 70 (64%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
15 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Mild to moderate depression per PHQ9 symptom ratings

Exclusion criteria

Exclusion Criteria:

  • active substance abuse/dependence
  • psychotic disorders
  • bipolar disorder
  • eating disorder
  • displaying acutely suicidal behaviors
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Personalized Behavioral Intervention

    Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns.

    Behavioral: Personalized Behavioral Intervention

Interventions

  • BehavioralPersonalized Behavioral Intervention

    Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns.

06

What researchers measure

Primary outcomes

  1. PHQ9

    Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome

    Time frame: 12 weeks

07

Study locations

1 site
  • UC San Diego Health Psychiatry
    San Diego, California 92127, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 27, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05662254
Lead sponsor
University of California, San Diego
Responsible party
Jyoti Mishra (Associate Professor, University of California, San Diego) — Principal investigator
First posted
Dec 22, 2022
Start date
Jun 1, 2022
Primary completion
Jul 15, 2024
Completion
Oct 11, 2024
Last update
Mar 27, 2025

Study contacts

Jyoti Mishra, PhD
principal investigator · University of California, San Diego

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.

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