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Not yet recruitingNCT05643287Updated Dec 18, 2024

The Effect of Time on the Outcome of Periodontal Treatment.

An interventional study of Periodontal treatment in Periodontitis, sponsored by 251 Hellenic Air Force & VA General Hospital. Not yet recruiting. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-18.

Sponsored by 251 Hellenic Air Force & VA General Hospital · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Primary completion was expected by Dec 2025, 10 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
75
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

Re-evaluation after non-surgical periodontal treatment remains an integral part of comprehensive periodontal therapy. This re-evaluation determines if a patient is in need either of surgical periodontal therapy or a personalized program of supportive periodontal treatment. However important, this time point is yet to be determined.This interventional study aims to clarify which is the best time to re-evaluate the therapeutic result after non-surgical periodontal treatment.

Read the detailed description

This randomized clinical trial aims to clarify which is the best time to re-evaluate the therapeutic result after non-surgical periodontal treatment. For this purpose the participants will be recruited among people who come to the Periodontal Department of 251 Hellenic Air Force Hospital for periodontal treatment. Each participant is going to submit informed consent in order to be included in the study. Patients with the diagnosis of Periodontitis will be submitted to non-surgical periodontal treatment with ultrasonic and manual scalers within two sessions, under local anaesthesia. The result of the treatment is going to be evaluated at 6, 12 and 24 weeks after treatment completion.

02

Conditions studied

  • Periodontitis

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Keywords

  • Periodontitis
  • Re-evaluation
  • Non-surgical periodontal treatment
03

In context

Periodontitis

1,664 studies on the registry are indexed under Periodontitis; 328 are open to participants now.

This study's planned enrollment of 75 is above the median of 45 across 1,206 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

251 Hellenic Air Force & VA General Hospital is the lead sponsor of 4 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Systematically healthy adults
  • Informed consent form completion
  • Periodontitis Diagnosis
  • Patients not having received periodontal treatment since 12 months before

Exclusion criteria

Exclusion Criteria:

  • Medical History that interferes with wound healing
  • Antibiotic and anti-inflammatory drugs intake
  • Medication that induces gingival enlargement
  • Pregnancy/ Lactation
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
75 participants (estimated)

Study arms

  • Experimental
    Periodontitis patients

    Periodontitis patients receiving non-surgical periodontal treatment.

    Procedure: Periodontal treatment

Interventions

  • ProcedurePeriodontal treatment

    Non-surgical periodontal treatment

06

What researchers measure

Primary outcomes

  1. Probing Pocket Depth 0

    The distance between the gingival margin and the base of the sulcus/pocket

    Time frame: Baseline

  2. Probing Pocket Depth 1

    The distance between the gingival margin and the base of the sulcus/pocket

    Time frame: 6 weeks after periodontal treatment

  3. Probing Pocket Depth 2

    The distance between the gingival margin and the base of the sulcus/pocket

    Time frame: 12 weeks after periodontal treatment

  4. Probing Pocket Depth 3

    The distance between the gingival margin and the base of the sulcus/pocket

    Time frame: 24 weeks after periodontal treatment

Secondary outcomes

  1. Clinical attachment level

    The distance between cementoenamel junction and the base of the sulcus/pocket

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  2. Plaque Index

    Number of sites with presence of dental plaque/ total number of sites

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  3. Bleeding on Probing

    Number of sites with presence of bleeding/total number of sites

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  4. Tooth Mobility

    degree of tooth mobility

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  5. Furcation involvement

    Presence or absence of furcation involvement and degree of furcation defect

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  6. matrix metalloproteinase

    matrix metalloproteinase 8 levels in whole saliva

    Time frame: Baseline, 6, 12, 24 weeks after treatment

  7. Oral Health Impact Profile (OHIP)-14 Questionnaire

    Questionnaire

    Time frame: Baseline, 6, 12, 24 weeks after treatment

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05643287
Lead sponsor
251 Hellenic Air Force & VA General Hospital
Responsible party
Georgia Malamoudi (Attendant at Periodontology Department of 251 Hellenic Air Force & VA Hospital, 251 Hellenic Air Force & VA General Hospital) — Principal investigator
First posted
Dec 8, 2022
Start date
Feb 3, 2025 (estimated)
Primary completion
Dec 2025 (estimated)
Completion
Dec 2025 (estimated)
Last update
Dec 18, 2024

Study contacts

Georgia Malamoudi, DDS,MSc
Contact
georgia.malamoudi@gmail.com
6983394983 ext. 0030
George Koukos, DDS,PhD
Contact
gkoukos1977@gmail.com
6983520282 ext. 0030
George Koukos, DDS, PhD
study director · 251 Hellenic Air Force & VA Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.

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