An observational study in Acute Pancreatitis, sponsored by Qatar University. Recruiting at 1 site in Qatar. Per ClinicalTrials.gov, last updated 2023-10-31.
Sponsored by Qatar University · Observational
This study aims to compare NS and LR in terms of outcomes in patients with acute pancreatitis while addressing the current methodological issues with available meta-analyses on the topic. Such comparison combined with bias adjustment will assist with identifying the optimal fluid rehydration therapy in acute pancreatitis, since most of the available data is conflicted around the topic. A database search will be conducted to identify studies comparing normal saline and ringer's lactate. Existing meta-analyses will be assessed. The results will be discussed in the light of their strengths and limitations and then any deficiencies will be addressed through a new synthesis as a final step of this umbrella review. The primary outcome will be SIRS at 24 hours. OR and 95% confidence intervals will be generated using the quality effects model. Heterogeneity will be evaluated using the I2 statistic. Publication bias will be assessed using the Doi Plot.
557 studies on the registry are indexed under Pancreatitis; 164 are open to participants now.
This study's planned enrollment of 500 is above the median of 200 across 192 observational studies indexed under Pancreatitis.
Browse Pancreatitis studies →Qatar University is the lead sponsor of 9 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult Patients diagnosed with Acute Pancreatitis (AP)
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Exclusion Criteria:
All studies will be reviewed in full form by each author to determine eligibility. In case of disagreement, determination of inclusion will be reached via consensus.
Systemic inflammatory response syndrome (SIRS)
SIRS is defined as two out of the following four criteria: a) Temperature\<36˚C (96.8˚F) or \>38˚C (100.4˚F) b) Heart rate\>90/min c) Respiratory rate\>20/min d) WBC(\<4000/mm3) (\>12,000/mm3) or 10% bands.
Time frame: at 24 hours
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Qatar University