An interventional study of pain delivery with capsaicin and heat and distractor delivery with sensory TENS in Pain, Acute and Cognition, sponsored by University of Delaware. Completed at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-11.
Sponsored by University of Delaware · Not applicable, Interventional, and Basic science
The effects of pain on cognitive performance have not been thoroughly investigated. Broadly, the purpose of this research is to investigate the effects of acute pain on performance of a variety of cognitive performance measures. The investigators hypothesize that acute pain impairs cognitive performance, particularly cognitive measures of working memory, attention, and processing speed.
876 studies on the registry are indexed under Acute Pain; 154 are open to participants now.
This study's enrollment of 23 is below the median of 90 across 732 interventional studies indexed under Acute Pain.
Browse Acute Pain studies →University of Delaware is the lead sponsor of 125 studies on the registry; 23 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Abbreviations: HR= heart rate, bpm= beats per minute; BP= blood pressure; ADD= attention deficit disorder; ADHD= attention deficit hyperactivity disorder; MoCA= Montreal Cognitive Assessment; GAD-7= Generalized Anxiety Disorder 7 Scale; PHQ-2, PHQ-9= Patient Health Questionnaire-2 and -9.
Inclusion Criteria:
Exclusion Criteria:
Capsaicin combined with heat applied to intact skin
Procedure: pain delivery with capsaicin and heat
Sensory transcutaneous electrical nerve stimulation (TENS) applied to intact skin
Procedure: distractor delivery with sensory TENS
Nothing applied to skin
Experimental pain paradigm delivered (capsaicin cream combined with heat) that is short-term and painful but not harmful
Distractor stimulus delivered (sensory TENS electrical stimulation) that is short-term and attention-demanding but not painful
Digit Span Forward & Backward Test
number of digits (numbers) that can be repeated back in the same (DS forward) or the reverse (DS backward( order from which they were presented
Time frame: the change between baseline and delivery (during application of intervention)
Trail Making Test A & B
time required to draw a line connecting a series of numbers (TM-A) or a series of alternating letters and numbers (TM-B)
Time frame: the change between baseline and delivery (during application of intervention)
Conner's Continuous Performance Test (CPT) 3
response time for letters vs. 'x' stimuli; number of correct inhibited responses
Time frame: the change between baseline and delivery (during application of intervention)
Hopkins Verbal Learning Test- Revised
verbal memory for 3 semantic categories of 4 nouns each; immediate and delayed recall
Time frame: the change between baseline and delivery (during application of intervention)
Brief Visuospatial Memory Test- Revised
visual memory for 6 shapes and their location on a page; immediate and delayed recall and recognition
Time frame: the change between baseline and delivery (during application of intervention)
Stroop Test
response time and number of errors when stating the name of words printed in a congruent, neutral or incongruent color compared to the meaning of the words
Time frame: the change between baseline and delivery (during application of intervention)
Wisconsin Card Sorting Test
number of trials taken to deduce the new rule when the rules of a card game are changed without warning and without knowing what any of the rules are
Time frame: the change between baseline and delivery (during application of intervention)
Delis Kaplan Executive Functional System (D-KEFS) - Verbal Fluency Section
number of words stated that match a certain category or start with a certain letter in a given time period
Time frame: the change between baseline and delivery (during application of intervention)
NIH Toolbox Picture Sequence
reproduce the correct sequence of pictures
Time frame: the change between baseline and delivery (during application of intervention)
NIH Toolbox Flanker
response time and errors when asked to focus on a single visual stimulus amongst distractors
Time frame: the change between baseline and delivery (during application of intervention)
NIH Toolbox List Sorting
recall and sequencing of different visually and orally presented stimuli
Time frame: the change between baseline and delivery (during application of intervention)
NIH Toolbox Dimension Change Card Sort
errors selecting the correct dimension upon which to select a card, a cue for which is provided
Time frame: the change between baseline and delivery (during application of intervention)
NIH Toolbox Pattern Comparison
errors and time required to determine whether several sets of two pictures are the same or not
Time frame: the change between baseline and during application of intervention
Wechsler 4th ed - Spatial Addition
errors and time required to add or subtract the location of circles on a screen based on a given set of rules
Time frame: the change between baseline and delivery (during application of intervention)
This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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University of Delaware