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Enrolling by invitationNCT05624632Updated Apr 2, 2024

Cognitive Remote Assessment Using FLAME (CRA-FLAME)

An observational study in Cognitive Impairment, sponsored by Barcelonabeta Brain Research Center, Pasqual Maragall Foundation. Enrolling by invitation at 1 site in Spain. Open to participants aged 45 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-04-02.

Sponsored by Barcelonabeta Brain Research Center, Pasqual Maragall Foundation · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2025, 10 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
400
Ages
45 Years to 80 Years
Sex
All
01

Study summary

We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment. We believe that this would provide critical information to move forward the current research framework in the field.

Participants will be selected from BBRC-sponsored studies, such as the ALFA project (STUDY 45-65 FPM/2012), the ALFA+ cohort study (ALFA - FPM - 0311), the Beta-AARC study (β-AARC_BBRC2020) or the BarcelonaBeta Dementia Prevention Research Clinic study (BBRC-DemPrev-2018)

Read the detailed description

We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment. We believe that this would provide critical information to move forward the current research framework in the field.

Participants will be selected from BBRC-sponsored studies, such as the ALFA project (STUDY 45-65 FPM/2012), the ALFA+ cohort study (ALFA - FPM - 0311), the Beta-AARC study (β-AARC_BBRC2020) or the BarcelonaBeta Dementia Prevention Research Clinic study (BBRC-DemPrev-2018)

02

Conditions studied

  • Cognitive Impairment
03

In context

Cognitive Dysfunction

3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.

This study's planned enrollment of 400 is above the median of 150 across 950 observational studies indexed under Cognitive Dysfunction.

Browse Cognitive Dysfunction studies →

Lead sponsor

Barcelonabeta Brain Research Center, Pasqual Maragall Foundation is the lead sponsor of 22 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 80 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Participants are individuals that have participated/are participating in BBRC-sponsored studies.

Inclusion criteria

Participants must meet ALL the following criteria:

  1. To sign the study informed consent form approved by the corresponding authorities.
  2. Men and women that have participated/are participating in a BBRC-sponsored study.
  3. To accept that:

    • The results obtained in this study may be published in scientific journals and at BBRC's communication channels (e.g. web page)
    • The data gathered may be used in combination with those gathered in other BBRC-sponsored studies in which they may (have) participate(d)

Exclusion criteria

Exclusion Criteria:

  1. Not having an ICT literacy enough to access and complete the online tests.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
400 participants (estimated)
Patient registry
No

Groups and cohorts

  • Cognitively unimpaired

    Cognitively unimpaired participants from BBRC-sponsored studies

    Other: Remote cognitive testing

Interventions

  • OtherRemote cognitive testing

    Remote cognitive testing

06

What researchers measure

Primary outcomes

  1. FLAME global composite score

    calculated by combining information from two web-based online neuropsychological test batteries that are already integrated in a unique platform: the PROTECT Cognitive Tests System (PCTS) (Corbett et al., 2015) and the CogTrackTM (Wesnes et al., 2017)

    Time frame: through study completion, an average of 3 years

07

Study locations

1 site
  • BarcelonaBeta Brain Research Center
    Barcelona, 08005, Spain
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 2, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05624632
Lead sponsor
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Responsible party
Sponsor
First posted
Nov 22, 2022
Start date
Dec 1, 2022
Primary completion
Dec 1, 2025 (estimated)
Completion
Dec 1, 2026 (estimated)
Last update
Apr 2, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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