ClinicalTrials.gg
Active, not recruitingNCT05622045StoryLCSSUpdated Jun 8, 2026

Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project)

An observational study in Obesity and Body Weight Changes, sponsored by Loma Linda University. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 74 Years. Per ClinicalTrials.gov, last updated 2026-06-08.

Sponsored by Loma Linda University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
59
Ages
18 Years to 74 Years
Sex
All
01

Study summary

The goal of this observational study is to learn about the personality attributes and values of people living with obesity that are part of the Latino community, and how these personality attributes and values can help to predict success during a weight loss program.

The main questions it aims to answer are:

  • What are the personality attributes and values of people living with obesity that sign up to the LCSS-Latino Crossover Semaglutide Study trial?
  • Can behavioral artificial intelligence (a computer formula) predict which patients will complete the LCSS-Latino Crossover Semaglutide Study trial?
  • How do behavioral artificial Intelligence predictions (a computer formula) compare to clinician predictions of patient success?
  • Can behavioral artificial intelligence (a computer formula) predict patient weight loss, calorie consumption and physical activity levels during the LCSS-Latino Crossover Semaglutide Study trial? Participants will be recorded in English and Spanish while responding to a question regarding participation in a weight loss study.
02

Conditions studied

  • Obesity
  • Body Weight Changes

Keywords

  • artificial intelligence
  • obesity
  • weight loss
03

In context

Obesity

11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.

This study's enrollment of 59 is below the median of 114 across 2,154 observational studies indexed under Obesity.

Browse Obesity studies →

Lead sponsor

Loma Linda University is the lead sponsor of 306 studies on the registry; 46 are open to participants now.

Of its 29 completed or terminated interventional studies of FDA-regulated products, 23 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 74 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Hispanic men and women, 18 to 74 years of age, with obesity, residing in Southern California, who are taking part in the LCSS-Latino Crossover Semaglutide Study.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Participation in the LCSS-Latino Crossover Semaglutide Study

Exclusion criteria

Exclusion Criteria:

  • Not a participant of the LCSS-Latino Crossover Semaglutide Study at the point of data collection
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
59 participants (actual)
Patient registry
No

Groups and cohorts

  • Story-LCSS

    Behavioral: Voice data

Interventions

  • BehavioralVoice data

    Recorded response to a question about their participation in a weight loss study.

This study also gives Semaglutide. No intervention listed here names it: that was found by reading the record.

06

What researchers measure

Primary outcomes

  1. Predicted patient weight change success

    Predicted patient weight change as determined by Scaled Insights Behavioural Artificial Intelligence based on subject voice data. Weight loss exceeding 5-10 pounds over 6 months will be considered to be successful. Predicted weight change will be compared to the weight change measured in a separate clinical trial \[Latino Crossover Semaglutide Study (LCSS) NCT05087342\]. Similar weight change values between the predicted and measured outcomes will indicate that the Scaled Insights Behavioural Artificial Intelligence is good predictor.

    Time frame: The voice data measurement will take place at baseline and take about 10-15 minutes for collection to take place.

  2. Clinician predictions

    Clinician (physician) judgement of patient weight loss success during a weight loss study.

    Time frame: The clinician judgement will be measured during the second month of the subject's weight loss study.

  3. Predicated patient calorie intake

    Predicted patient calorie intake as determined by Scaled Insights Behavioural Artificial Intelligence based on subject voice data. Predicted calorie intake will be compared to the calorie intake measured in a separate clinical trial \[Latino Crossover Semaglutide Study (LCSS) NCT05087342\]. Similar calorie values between the predicted and measured outcomes will indicate that the Scaled Insights Behavioural Artificial Intelligence is good predictor.

    Time frame: The voice data measurement will take place during the subject's initial clinic visit and take about 10-15 minutes for collection to take place.

  4. Predicated patient physical activity level

    Predicted patient physical activity level as determined by Scaled Insights Behavioural Artificial Intelligence based on subject voice data. Predicted physical activity will be compared to the physical activity measured in a separate clinical trial \[Latino Crossover Semaglutide Study (LCSS) NCT05087342\]. Similar physical activity level values between the predicted and measured outcomes will indicate that the Scaled Insights Behavioural Artificial Intelligence is good predictor.

    Time frame: The voice data measurement will take at baseline and take about 10-15 minutes for collection to take place.

Secondary outcomes

  1. Personality attributes and values

    Extrapolated personality attributes and values as determined by Scaled Insights Behavioural Artificial Intelligence based on subject voice data. These are qualitative non-numerical descriptors.

    Time frame: The voice data measurement will take place at baseline and take about 10-15 minutes for collection to take place.

  2. Predicted patient attrition rate

    Predicted patient attrition rate from the weight loss study as determined by Scaled Insights Behavioural Artificial Intelligence based on subject voice data. Predicted patient attrition rate will be compared to the attrition rate occurring during the weight loss study. Similar attrition rates between the predicted and actual rates will indicate that the Scaled Insights Behavioural Artificial Intelligence is good predictor.

    Time frame: The voice data measurement will take place at baseline and take about 10-15 minutes for collection to take place.

07

Study locations

1 site
  • Nutrition Research Center, School of Public Health, Loma Linda University
    Loma Linda, California 92350, United States
08

References and documents

Publications

  • Alberga AS, Russell-Mayhew S, von Ranson KM, McLaren L. Weight bias: a call to action. J Eat Disord. 2016 Nov 7;4:34. doi: 10.1186/s40337-016-0112-4. eCollection 2016. PubMed 27826445 ↗
  • Dalle Grave R, Calugi S, Compare A, El Ghoch M, Petroni ML, Tomasi F, Mazzali G, Marchesini G. Weight Loss Expectations and Attrition in Treatment-Seeking Obese Women. Obes Facts. 2015;8(5):311-8. doi: 10.1159/000441366. Epub 2015 Oct 8. PubMed 26444382 ↗
  • Flint SW, Leaver M, Griffiths A, Kaykanloo M. Disparate healthcare experiences of people living with overweight or obesity in England. EClinicalMedicine. 2021 Sep 15;41:101140. doi: 10.1016/j.eclinm.2021.101140. eCollection 2021 Nov. PubMed 34585130 ↗
  • Flint SW, Piotrkowicz A, Watts K. Use of Artificial Intelligence to understand adults' thoughts and behaviours relating to COVID-19. Perspect Public Health. 2022 May;142(3):167-174. doi: 10.1177/1757913920979332. Epub 2021 Jan 21. PubMed 33472547 ↗
  • Hardcastle SJ, Taylor AH, Bailey MP, Harley RA, Hagger MS. Effectiveness of a motivational interviewing intervention on weight loss, physical activity and cardiovascular disease risk factors: a randomised controlled trial with a 12-month post-intervention follow-up. Int J Behav Nutr Phys Act. 2013 Mar 28;10:40. doi: 10.1186/1479-5868-10-40. PubMed 23537492 ↗
  • Puhl RM, Phelan SM, Nadglowski J, Kyle TK. Overcoming Weight Bias in the Management of Patients With Diabetes and Obesity. Clin Diabetes. 2016 Jan;34(1):44-50. doi: 10.2337/diaclin.34.1.44. No abstract available. PubMed 26807008 ↗
  • Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PubMed 33567185 ↗

Individual participant data

Plan to share: Undecided — There is not plan currently to share IPD outside of the collaborators that are part of the study. It is possible that requests may be made by students later on to use data for secondary data analysis as part of their academic research projects, and the research collaborators will decide if unidentified IPD would be shared at such a time.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Feb 2023 to primary completion in May 2024, 15 months.

Of 791 non-industry observational studies under Obesity, half reached primary completion within 40 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 106. This study's 15 months is below that.

Counting every sponsor, half of 836 studies reached it within 39 months; a quarter within 17 and three quarters within 96.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 7, 2022
First posted
Nov 18, 2022
StartActual
Feb 1, 2023
Primary completionActual
May 29, 2024
CompletionEst.
May 2027
Last update
Jun 8, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05622045
Collaborators
Scaled Insights
Responsible party
Sponsor
First posted
Nov 18, 2022
Start date
Feb 1, 2023
Primary completion
May 29, 2024
Completion
May 2027 (estimated)
Last update
Jun 8, 2026

Study contacts

Celine Heskey, DrPH
principal investigator · Loma Linda University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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