An observational study in Acute Kidney Injury and Cancer Colorectal, sponsored by Uppsala University. Active, not recruiting at 1 site in Sweden. Per ClinicalTrials.gov, last updated 2024-05-08.
Sponsored by Uppsala University · Observational
The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of acute kidney injury.
The main questions it aims to answer are:
The study will analyze data from the CAN clinical trial database. (Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia, NCT01975064)
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
This study's planned enrollment of 4,000 is above the median of 150 across 773 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Uppsala University is the lead sponsor of 381 studies on the registry; 84 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who underwent colorectal cancer resection surgery and gave consent to participate in the CAN trial.
Exclusion Criteria:
The group of patients which received sevoflurane as randomized anesthetic modality.
Drug: Anesthesia Agent
The group of patients which received propofol as randomized anesthetic modality.
Drug: Anesthesia Agent
The two anesthetic modalities included intravenous propofol anesthesia and sevoflurane gas anesthesia administered according to standard clinical praxis.
Acute Kidney Injury
Compare the incidence of AKI (n, %) in the two anesthetic modalities. Number of participants (n, %) with AKI and number of participants (n, %) with AKI stage 1-3 within the different anesthetic modalities at 0-3 days and 4-10 days postoperatively. KDIGO (Kidney Disease: Improving Global Outcome) criteria for plasma creatinine are used as criteria for AKI. The highest value of plasma creatinine within the time frame will be used to define AKI stage.
Time frame: Within 10 days of surgery
Changes in plasma creatinine
Changes in plasma creatinine over time in both groups of anesthesia. Plasma creatinine from preoperative, postoperative after 0-3 days, postoperative 4-10 days and after 30 days. Maximum plasma creatinine for each participant at these time point will be used in the regression analysis.
Time frame: Within 30 days of surgery
AKI incidence in the cardiovascular disease population
Compare the incidence of AKI (n, %) during the two anesthetic modalities in the population with present cardiovascular disease. Classified according to KDIGO AKI stage 1-3 changes in plasma creatinine. The highest value of plasma creatinine within the time frame will be used to define AKI stage.
Time frame: Within 10 days of surgery
Association of sex on AKI incidence
Compare the incidence of AKI (n, %) in men vs women. This analysis will be done in both groups separately and in the entire population independent of anesthetic modality.
Time frame: Within 10 days of surgery
Association of age on AKI incidence
Compare the incidence of AKI (n, %) in participants older vs younger than 65. This analysis will be done in both groups separately and in the entire population independent of anesthetic modality.
Time frame: Within 10 days of surgery
Plan to share: No
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This study is active, not recruiting, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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Uppsala University