An observational study in Drug Use, sponsored by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer. Completed at 61 sites in 3 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Observational
Environmental awareness leads medical field to question its responsibility and possibilities for action.
Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice, this is not systematic. Moreover, data on drug wastage in Intensive Care Units (ICU) are rare.
GAME-OVER observational study aims to evaluate drug wastage in ICU in France and to suggest ways to improve health care practices.
Observational study with data collection during a 24-hour business day. Data collected refer to healthcare team's practices and patients.
Collection starts when day shift starts (at 7:00 am) and ends when night shift leaves (at 7:00 am the following day).
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer is the lead sponsor of 78 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients hospitalized in intensive care units during the 24 hours of data collection.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patient and prepared/administrated/discarded IV drugs data will be collected during 24 hours.
Other: Quantification of IV drugs wastage
Drugs are prescribed depending on physician discretion. Specific collection bins are provided to ICU. Healthcare teams discard syringes labelled with name and dilution which have been used to prepare drugs into these bins. After 24 hours of collection, bins are analyzed by investigators.
Ratio of overall wastage in milliliter (mL) of prepared and discarded IV drugs to overall volume in milliliter (mL) of prepared IV drugs.
Wastage is defined as any prepared and unused drug that remains in syringe or IV bag.
Time frame: 24 hours
Reason for discarding drug residues
A questionnaire will be fulfilled by healthcare teams with the following possible categories: 1/ prepared in advance and not used ; 2/ systematic change at fixed times ; 3/ prescription change ; 4/ change by anticipation of care ; 5/ drug no longer needed ; 6/ preparation error ; 7/ other reason.
Time frame: 24 hours
Drug residues discarding process
A questionnaire will be used to determine which discarding process are applied by nurses in their usual pratices.
Time frame: 24 hours
Use of enteral administration route
Use of enteral administration route versus per os and IV routes will be analyzed for paracetamol and proton pump inhibitor according to the accessibility of enteral route and the reason and the date of patient entry in ICU.
Time frame: 24 hours
Cost of overall IV drug wastage
Estimated cost of drug residues will be evaluated for each drug, according to the reason for discarding, by the following formula : volume of discarded IV drugs x theoretical price
Time frame: 24 hours
Plan to share: No
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer