CompletedNCT05538793Updated Oct 27, 2023

Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study

An observational study in Keratitis, Automatic Judgement and Image, sponsored by Ningbo Eye Hospital. Completed at 2 sites in China. Open to participants aged 1 Week to 100 Years. Per ClinicalTrials.gov, last updated 2023-10-27.

Sponsored by Ningbo Eye Hospital · Observational

Study type: Observational
Model: Other
Time perspective: Other
Enrollment: 10,369
Ages: 1 Week to 100 Years
Sex: All

Study summary

Detecting the cause of keratitis fast is the premise of providing targeted therapy for reducing vision loss and preventing severe complications. Due to overlapping inflammatory features, even expert cornea specialists have relatively poor performance in the identification of causative pathogen of infectious keraitis. In this project, the investigators aim to develop an automated and accurate deep learning system to discriminate among bacterial, fungal, viral, amebic and noninfectious keratitis based on slit-lamp images and evaluated this system using the datasets obtained from mutiple independent clinical centers across China.

Conditions studied

Keratitis
Automatic Judgement
Image

Browse trials for

Keratitis 108

Keywords

Keratitis
Slit-lamp Image
Deep Learning

In context

Keratitis

108 studies on the registry are indexed under Keratitis; 19 are open to participants now.

This study's enrollment of 10,369 is above the median of 105 across 31 observational studies indexed under Keratitis.

Browse Keratitis studies →

Lead sponsor

Ningbo Eye Hospital is the lead sponsor of 4 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 1 Week to 100 Years
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

Child, Adult, Older Adult

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Slit-lamp images with sufficient diagnostic certainty and showing keratitis at the active phase.

Exclusion criteria

Exclusion Criteria:

Poor-quality images
Images presenting mixed infections (i.e., cornea infected by two or more causative pathogens)

Study design

Observational model: Other
Time perspective: Other
Enrollment: 10,369 participants (actual)
Patient registry: No

What researchers measure

Primary outcomes

Area under the receiver operating characteristic curve of the deep learning system
Time frame: 2020-2022

Secondary outcomes

Accuracy of the deep learning system
Time frame: 2020-2022
Sensitivity of the deep learning system
Time frame: 2020-2022
Specificity of the deep learning system
Time frame: 2020-2022

Study locations

2 sites

Ningbo Eye Hospital
Ningbo, Zhejiang, China
Eye Hospital of Wenzhou Medical University
Wenzhou, China

Timeline

Tracking since Sep 25, 2026

ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jul 2020 to primary completion in Sep 2023, 38 months.

Of 16 observational studies under Keratitis, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 34. This study's 38 months is above that.

How these figures are worked out, and which studies are left out of them.

Registered: Sep 11, 2022
First posted: Sep 14, 2022
StartActual: Jul 1, 2020
Primary completionActual: Sep 30, 2023
CompletionActual: Oct 20, 2023
Last update: Oct 27, 2023

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Oct 27, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT05538793
Lead sponsor: Ningbo Eye Hospital
Responsible party: Sponsor
First posted: Sep 14, 2022
Start date: Jul 1, 2020
Primary completion: Sep 30, 2023
Completion: Oct 20, 2023
Last update: Oct 27, 2023

Oversight

Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.

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Discussion

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