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CompletedNCT05537116Updated Aug 31, 2026Results posted

Evaluation of an Interactive Mobile Phone-Based Brief Intervention to Reduce Substance-Impaired Driving

An interventional study of Personalized feedback and Personalized feedback and text messages in Driving Impaired, sponsored by Western Kentucky University. Completed at 1 site in United States. Open to participants aged 18 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-31.

Sponsored by Western Kentucky University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
149
Allocation
Randomized
Ages
18 Years to 29 Years
Sex
All
01

Study summary

Substance-Impaired Driving among emerging adults remains a significant public health concern and may be the single riskiest substance-related outcome among young adults. Brief Interventions (BIs) have been shown to reduce alcohol-impaired driving among this age group, but are not often implemented - despite their demonstrated efficacy - because it is not economically feasible to deliver in-person BIs to all emerging adult substance users. The present study will be the first to examine whether a text-messaging-based cannabis-impaired driving BI significantly decreases cannabis-impaired driving among emerging adult cannabis users compared to an informational control. Participants will be 149 emerging adults who endorse driving after cannabis use (or combined alcohol and cannabis use) at least three times in the past 3 months. After completing baseline measures, participants will be randomly assigned to receive either: a) substance use information, b) a substance-impaired driving personalized feedback intervention, or c) a substance-impaired driving personalized feedback intervention plus interactive text messages. Participants will complete outcome measures 3 and 6 months post-intervention. Repeated measures mixed modeling analyses will be used to determine whether the intervention significantly reduces substance-impaired driving over time. The project has two specific aims: 1) to evaluate a text based cannabis-impaired driving intervention in a randomized clinical trial, and 2) to determine whether the use of interactive text-messages sustains intervention effects over time.

Read the detailed description

Rates of substance-impaired driving remain especially high among emerging adults, and substance-related traffic accidents remain the leading cause of substance-related death in this age group. Although rates of alcohol-impaired driving (AI-driving) among emerging adults have begun to decrease, rates of driving after cannabis use (DACU) continue to rise. In addition, many emerging adults report simultaneous use of alcohol and cannabis, a behavior that has been shown to increase the odds of substance-impaired driving and results in substantially greater fatal crash risk. Brief Interventions (BIs) have been shown to decrease substance use and related problems.6 BIs attempt to identify and correct faulty normative beliefs and highlight personal consequences of substance use (such as driving after substance use). BIs typically consist of one or two individual therapeutic meetings delivered in motivational interviewing (MI) style and include personalized feedback (based on a series of questionnaires completed by the participant prior to their BI session). One reason why BIs have not been widely implemented- despite their demonstrated efficacy - is that it is not economically feasible for universities and community agencies to hire and train staff to deliver in-person BIs to all substance users, and very few emerging adults seek out substance prevention or treatment services available on campus or in the surrounding community. Innovative ways of delivering BIs to this at-risk population, in a manner that is both effective and economically feasible, need to be developed. Text messaging represents a particularly advantageous way to provide BIs as they can be highly personalized to the individual and allows for engagement and interaction between the interventionist and participant. Research indicates that emerging adults prefer text messages to telephone calls and emails and rate this medium positively. Given the high prevalence and fatal consequences of substance-impaired driving, highly accessible intervention approaches are imperative for reducing this extremely risky behavior.

In the past few years, a number of interventions using text-messaging to target substance use and problems have been developed and evaluated with reviews and meta-analyses suggesting that the majority of these interventions result in improved outcomes and warrant further large scale studies. Most of these interventions target overall substance use and problems and do not focus on specific risk behaviors, such as substance-impaired driving. We have developed and evaluated a mobile-based BI focused specifically on decreasing AI-driving among college students in a pilot trial. This study indicated that a brief, mobile-based AI-driving intervention including MI text messaging resulted in significantly greater reductions in AI-driving at the 3-month follow-up, compared to alcohol information alone. We modified the intervention to focus on driving after cannabis use and found that the intervention resulted in significantly greater increases in perceived dangerousness of DACU and significantly greater decreases in DACU compared to to an informational control condition. Importantly, several recent studies have demonstrated greater effectiveness of interventions that include personal contact vs. those that are fully automated. The present study provides an important bridge between in-person therapist delivered interventions and fully automated interventions by utilizing interactive text messaging with participants in order to enhance retention of intervention elements and provide tailored, individualized interaction. It is imperative to directly test whether the use of interactive text-messages decreases substance-impaired driving significantly more than personalized feedback alone.

The proposed study will extend promising pilot results by: (a) increasing power by recruiting 149 emerging adults reporting recent driving after cannabis use (DACU), (b) including a 6-month follow-up to determine whether intervention effects persist over time, (c) examining mediators of intervention outcomes (e.g., changes in cannabis-related cognitions), and (d) providing additional intervention content focused on decreasing driving after combined use of alcohol and cannabis. The overarching goal is to use mobile technology to reduce driving after substance use among emerging adult cannabis users.

We will conduct a 3-group trial with 149 emerging adults (ages 18-25; project 50% female; 20% minority) recruited from a community in the Southeastern United States.

Group 1: substance impaired driving personalized feedback Group 2: substance impaired driving personalized feedback and Motivational Interviewing (MI) interactive text messages Group 3: substance use information (control) Aim 1: Evaluate a text based substance-impaired driving intervention in a Randomized Clinical Trial.

Hypothesis 1: Group 2 will report greater reductions in driving after cannabis use and driving after simultaneous alcohol and cannabis use 3- and 6-months post-intervention.

Aim 2: Evaluate mechanisms of intervention response. Hypothesis 1: Cognitive factors (e.g., changes in perceptions of dangerousness and consequences, peer norms, cannabis expectancies) will mediate intervention outcomes.

02

Conditions studied

  • Driving Impaired
03

Who can participate

Ages eligible
18 Years to 29 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age 18 or older
  • Ability to speak, read, and write in English
  • Reports driving after using cannabis prior to driving at least three times in the past three months
  • Reports having access to a motor vehicle, a valid driver's license, and plans to drive a vehicle in the next 6 months
  • Reports access to a cell phone and willingness to read intervention material and exchange 3 texts post intervention with the study administrator
  • Reports a valid email address

Exclusion criteria

Exclusion Criteria:

  • Currently in treatment for substance use
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
149 participants (actual)

Study arms

  • Experimental
    Personalized Feedback

    Following the baseline assessment, participants will be sent a link via text message to a secure website containing substance-impaired driving specific personalized feedback. Feedback will include the following elements: a personalized substance use profile and substance-impaired driving profile, information on social norms related to substance use and substance-impaired driving, personalized information on BAC (or level of impairment due to drug use) prior to driving, costs associated with a DUI citation in Kentucky, and information on combined drug and alcohol impaired driving risk (if endorsed).

    Behavioral: Personalized feedback

  • Experimental
    Personalized feedback and text messages

    Following the baseline assessment, participants will be sent a link via text message to a secure website containing substance-impaired driving specific personalized feedback (described above). Participants will be asked to send a text message back to the study administrator after viewing the feedback document. After confirming receipt and processing of the document, the study administrator will then send the participant three text messages containing open-ended questions.

    Behavioral: Personalized feedback and text messages

  • Active comparator
    Information only

    Students randomized to the information condition will receive standard information about alcohol and other drugs and substance-impaired driving via a link to a website delivered through text message.

    Behavioral: Information Only

Interventions

  • BehavioralPersonalized feedback

    Following the baseline assessment, participants will be sent a link via text message to a secure website containing substance-impaired driving specific personalized feedback. Feedback will include the following elements: a personalized substance use profile and substance-impaired driving profile, information on social norms related to substance use and substance-impaired driving, personalized information on BAC (or level of impairment due to drug use) prior to driving, costs associated with a DUI citation in Kentucky, and information on combined drug and alcohol impaired driving risk (if endorsed).

  • BehavioralPersonalized feedback and text messages

    Following the baseline assessment, participants will be sent a link via text message to a secure website containing substance-impaired driving specific personalized feedback (described above). Participants will be asked to send a text message back to the study administrator after viewing the feedback document. After confirming receipt and processing of the document, the study administrator will then send the participant three text messages containing open-ended questions.

  • BehavioralInformation Only

    Students randomized to the information condition will receive standard information about alcohol and other drugs and substance-impaired driving via a link to a website delivered through text message.

05

What researchers measure

Primary outcomes

  1. Driving After Cannabis Use

    Self-reported count of driving-after-cannabis-use episodes during the prior 3 months, assessed at the 3-month post-intervention follow-up.

    Time frame: 3-month post-intervention follow-up assessment

  2. Driving After Cannabis Use

    Self-reported number of times participants drove after cannabis use during the prior 3 months, assessed at the 6-month post-intervention follow-up.

    Time frame: 6 months post-intervention follow-up assessment

Secondary outcomes

  1. Driving After Combined Alcohol and Cannabis Use

    Self-reported number of times participants drove after combined alcohol and cannabis use during the prior 3 months, assessed at the 3-month post-intervention follow-up.

    Time frame: 3-month post-intervention follow-up assessment

  2. Driving After Combined Alcohol and Cannabis Use

    Self-reported number of times participants drove after combined alcohol and cannabis use during the prior 3 months, assessed at the 6-month post-intervention follow-up.

    Time frame: 6 months post-intervention follow-up assessment

06

Results

Posted Aug 31, 2026

Participant flow

Lab personnel recruited emerging adults from communities surrounding Bowling Green, KY. Flyers were strategically placed around campus and around community locations frequented by emerging adults within 60 miles of campus. Additionally, targeted advertisements were placed on Facebook and Instagram.

Participant flow — Overall Study
MilestonePersonalized FeedbackPersonalized Feedback and Text MessagesInformation Only
Started504554
Completed504554
Not completed000

Outcome measures

PrimaryDriving After Cannabis Use

Self-reported count of driving-after-cannabis-use episodes during the prior 3 months, assessed at the 3-month post-intervention follow-up.

Time frame:
3-month post-intervention follow-up assessment
Reported as:
Mean · Driving events
Driving After Cannabis Use
Driving eventsPersonalized FeedbackPersonalized Feedback and Text MessagesInformation Only
Driving After Cannabis Use13.86 ± 19.9014.72 ± 21.7820.15 ± 27.79
SecondaryDriving After Combined Alcohol and Cannabis Use

Self-reported number of times participants drove after combined alcohol and cannabis use during the prior 3 months, assessed at the 3-month post-intervention follow-up.

Time frame:
3-month post-intervention follow-up assessment
Reported as:
Mean · Driving events
Driving After Combined Alcohol and Cannabis Use
Driving eventsPersonalized FeedbackPersonalized Feedback and Text MessagesInformation Only
Driving After Combined Alcohol and Cannabis Use1.16 ± 3.152.05 ± 7.570.80 ± 2.53
PrimaryDriving After Cannabis Use

Self-reported number of times participants drove after cannabis use during the prior 3 months, assessed at the 6-month post-intervention follow-up.

Time frame:
6 months post-intervention follow-up assessment
Reported as:
Mean · Driving events
Driving After Cannabis Use
Driving eventsPersonalized FeedbackPersonalized Feedback and Text MessagesInformation Only
Driving After Cannabis Use8.40 ± 15.7317.45 ± 25.2617.23 ± 23.22
Statistical analysis
  • Personalized Feedback and Text Messages vs Information Only · Mixed Models Analysis · p = 0.043 · Incidence rate ratio (irr): 0.53 · 95% CI 0.29 to 0.98
  • Personalized Feedback vs Information Only · Mixed Models Analysis · p = 0.016 · Incidence rate ratio (irr): 0.47 · 95% CI 0.25 to 0.87
SecondaryDriving After Combined Alcohol and Cannabis Use

Self-reported number of times participants drove after combined alcohol and cannabis use during the prior 3 months, assessed at the 6-month post-intervention follow-up.

Time frame:
6 months post-intervention follow-up assessment
Reported as:
Mean · Driving events
Driving After Combined Alcohol and Cannabis Use
Driving eventsPersonalized FeedbackPersonalized Feedback and Text MessagesInformation Only
Driving After Combined Alcohol and Cannabis Use0.36 ± 1.041.24 ± 3.493.44 ± 10.66
Statistical analysis
  • Personalized Feedback and Text Messages vs Information Only · Mixed Models Analysis · p = 0.86 · Incidence rate ratio (irr): 2.12 · 95% CI 0.34 to 13.4

Adverse events

Collected over Adverse events were not systematically collected in this study.. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Personalized Feedback———
Personalized Feedback and Text Messages———
Information Only———

Baseline characteristics

No participants assigned to conditions were excluded from analyses at baseline.

Age, Continuous
Age, Continuous(Years)Personalized FeedbackPersonalized Feedback and Text MessagesInformation OnlyTotal
Mean20.18 ± 2.0021.07 ± 3.2220.87 ± 2.9820.70 ± 2.78
Sex/Gender, Customized
Sex/Gender, Customized(Participants)Personalized FeedbackPersonalized Feedback and Text MessagesInformation OnlyTotal
Female333037100
Male11141439
Other selected52310
Race/Ethnicity, Customized
Race/Ethnicity, Customized(Participants)Personalized FeedbackPersonalized Feedback and Text MessagesInformation OnlyTotal
White403545120
Black/African American55212
More than one race23510
Asian1102
Unknown2125
Driving after cannabis use in the past 3 months
Driving after cannabis use in the past 3 months(Driving events)Personalized FeedbackPersonalized Feedback and Text MessagesInformation OnlyTotal
Mean21.18 ± 24.7528.93 ± 28.7625.31 ± 28.1825.02 ± 27.25
Driving after combined alcohol and cannabis use in the past 3 months
Driving after combined alcohol and cannabis use in the past 3 months(Driving events)Personalized FeedbackPersonalized Feedback and Text MessagesInformation OnlyTotal
Mean3.46 ± 13.198.73 ± 21.385.48 ± 15.965.76 ± 16.97
07

Study locations

1 site
  • Kelly Thompson Hall
    Bowling Green, Kentucky 42101, United States
08

References and documents

Publications

  • Teeters JB, Ramirez AB, Meredith ND. Cannabis use frequency and driving safety: Associations between cannabis use frequency and driving perceptions and behaviors. Psychol Addict Behav. 2026 Mar 19:10.1037/adb0001145. doi: 10.1037/adb0001145. Online ahead of print. PubMed 41854673 ↗

Study documents

  • Protocol and statistical analysis plan · Jul 21, 2021

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: Yes — The final dataset will consist of self-reported data from survey questionnaires and qualitative data from text-messaging sessions. Preliminary data will be shared via a presentation at a national conference in the second and third years of the project. After all data is collected, a manuscript detailing findings from the study will be submitted for peer-review and de-identified data will be submitted to the NIDA data archive.

Supporting information: Study protocol, Sap, Icf

09

Registry details

Key details

Study ID
NCT05537116
Lead sponsor
Western Kentucky University
Responsible party
Sponsor
First posted
Sep 13, 2022
Start date
Oct 18, 2022
Primary completion
Sep 8, 2025
Completion
Mar 31, 2026
Results posted
Aug 31, 2026
Last update
Aug 31, 2026

Study contacts

Jenni Teeters, PhD
principal investigator · Western Kentucky University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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