A Phase 2 interventional study of Olfactory mucosa-derived mesenchymal stem cells and Patients treated according to current clinical protocols in Tracheal Stenosis and Laryngeal Stenosis, sponsored by Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus. Status unknown at 1 site in Belarus. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2022-09-10.
Sponsored by Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Phase 2, Interventional, and Treatment
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
Trial evaluating the safety and efficacy of olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis with/without cartilage defects
Mesenchymal stem cells are obtained from tissue biopsy of olfactory mucosa using explant method. Biomass of autologous mesenchymal stem cells in 10% human albumin solution is injected submucosally around and over the tissue after removal of a granuloma tissue during surgical intervention.
42 studies on the registry are indexed under Tracheal Stenosis; 11 are open to participants now.
This study's planned enrollment of 20 is close to the median of 22 across 24 interventional studies indexed under Tracheal Stenosis.
Browse Tracheal Stenosis studies →Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus is the lead sponsor of 25 studies on the registry; 1 is open to participants now.
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-confirmed diagnosis of chronic laryngeal or tracheal stenosis;
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with tracheal/laryngeal stenosis receiving standard surgical treatment and mesenchymal stem cells
Biological: Olfactory mucosa-derived mesenchymal stem cells · Other: Patients treated according to current clinical protocols
Patients with tracheal/laryngeal stenosis receiving standard surgical treatment
Other: Patients treated according to current clinical protocols
Autologous olfactory mucosa-derived mesenchymal stem cells
Patients treated according to current clinical protocols
Number of patients who didn't require the repeated surgical interventions
Relative number of patients who didn't require the repeated surgical interventions after MSC therapy
Time frame: 1 year
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
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Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus