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CompletedNCT05529524Updated Jan 24, 2025

Signatures of Response and Resistance to Mosunetuzomab in Follicular Lymphomas (FL)

An observational study in Follicular Lymphoma, sponsored by The Lymphoma Academic Research Organisation. Completed at 9 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-01-24.

Sponsored by The Lymphoma Academic Research Organisation · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
6
Ages
18 Years and older
Sex
All
01

Study summary

Mosunetuzumab is a T-cell bispecific antibody targeting CD20 and CD3 aiming to redirect T cells to engage and eliminate malignant B cells. Bispecific antibodies (BsAb) are a promising treatment option which can induce long-term responses in refractory and relapsed B cell lymphoma patients. However, the factors determining the quality and duration of responses are poorly understood.

Read the detailed description

the objective is to produce a collection of great scientific interest for lymphoma research from CELESTIMO's clinical trial patients' samples to increase knowledge of treatment with mosunetuzumab's for patients with follicular lymphoma (FL).

study population involves patients participating to CELESTIMO study in France. 10 sites are expected in this biobanking protocol study

Biological samples will collected as part of routine care (tissue and blood already sampled in routine and/or CELESTIMO study) at screening, at C4, at C12 or at progressive disease/relapse.

02

Conditions studied

  • Follicular Lymphoma

Keywords

  • Follicular Lymphoma
  • Mosunetuzomab
  • Resistance
  • CD20-CD3
  • Bispecific antibodies
  • Neoplasms
  • Lymphatic Diseases
  • Immunoproliferative Disorders
03

In context

Lymphoma

5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.

This study's enrollment of 6 is below the median of 136 across 625 observational studies indexed under Lymphoma.

Browse Lymphoma studies →

Lead sponsor

The Lymphoma Academic Research Organisation is the lead sponsor of 60 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients who participate to CELESTIMO study (NCT04712097)

Eligibility criteria

patients who participate to CELESTIMO study (NCT04712097)

05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
6 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. Capacity of sampling

    number of samples collected

    Time frame: 2 years

07

Study locations

9 sites
  • Centre Hospitalier de La Cote Basque; Hematologie
    Bayonne, 64109, France
  • Hopital Claude Huriez; Hematologie
    Lille, 59037, France
  • Institut Paoli Calmettes
    Marseille, 13273, France
  • CHU Saint Eloi; Service d'Hématologie Clinique
    Montpellier, 34295, France
  • CHU NANTES - Hôtel Dieu; Service d'Hematologie Clinique
    Nantes cedex 1, 44000, France
  • CHU de Nîmes - Hôpital Carémeau
    Nîmes, 30029, France
  • Hopital Saint Antoine; Hematologie Clinique
    Paris, 75012, France
  • Hopital De La Miletrie; Hematologie Et Oncologie Medicale
    Poitiers, 86021, France
  • CHU Pontchaillou
    Rennes, 35033, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 24, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05529524
Lead sponsor
The Lymphoma Academic Research Organisation
Collaborators
Roche Pharma AG
Responsible party
Sponsor
First posted
Sep 7, 2022
Start date
Nov 7, 2022
Primary completion
Jan 22, 2024
Completion
Jan 22, 2024
Last update
Jan 24, 2025

Study contacts

Camille Laurent, MD
principal investigator · Oncopole - Toulouse France
Karin Tarte, PhD
principal investigator · Micro-environnement et cancer (MICA) - Rennes France
Franck MORSCHHAUSER, MD
principal investigator · Centre Hospitalier Universitaire de Lille - Lille France

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.

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