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RecruitingNCT05521503BICARDUpdated Feb 3, 2026

Biopsy Collection and Repository Database

An observational study in Cardiovascular Diseases, sponsored by Kenneth S. Campbell. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-03.

Sponsored by Kenneth S. Campbell · Observational

From the registry’s dates

  • Started Dec 2021; still recruiting 4 years 9 months later.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
400
Ages
18 Years and older
Sex
All
01

Study summary

Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.

Read the detailed description

This is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.

02

Conditions studied

  • Cardiovascular Diseases
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's planned enrollment of 400 is below the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

Kenneth S. Campbell is the lead sponsor of 2 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.

Inclusion criteria

  • All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.

Exclusion criteria

Exclusion Criteria:

  • Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
400 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Biological specimens

    Biological specimens taken from cardiovascular procedures

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What researchers measure

Primary outcomes

  1. Discover and quantify the concentration of novel diagnostic and prognostic biomarkers

    Use biospecimens procured from patients with cardiac conditions to identify diagnostic surrogate biomarkers using discovery proteomics. In Cardiac Amyloidosis, the serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established. The research aims to advance understanding of cardiac diseases and to support the development of improved therapies.

    Time frame: 12/21/2021-12/31/2030

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Study locations

1 of 1 sites recruiting
  • University of Kentucky
    Lexington, Kentucky 40536, United States
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 3, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05521503
Lead sponsor
Kenneth S. Campbell
Responsible party
Kenneth S. Campbell (Associate Professor, University of Kentucky) — Sponsor-investigator
First posted
Aug 30, 2022
Start date
Dec 21, 2021
Primary completion
Dec 2030 (estimated)
Completion
Dec 2030 (estimated)
Last update
Feb 3, 2026

Study contacts

Kenneth S Campbell, PhD
Contact
k.s.campbell@uky.edu
(859) 323-8157
Jennifer Isaacs, MS, MS
Contact
jennifer.isaacs@uky.edu
(859) 323-4738
Kenneth S Campbell, PhD
principal investigator · University of Kentucky

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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