An observational study in Acute Heart Failure and Diagnosis, sponsored by University of Edinburgh. Active, not recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-03.
Sponsored by University of Edinburgh · Observational
Acute heart failure is a life-threatening condition where the heart is suddenly unable to pump blood around the body. It can be challenging to diagnose because the symptoms often mimic other conditions. Previous studies have showed that delays in making the correct diagnosis result in worse outcomes. We therefore developed a decision-support tool called CoDE-HF that uses a computer algorithm to combine levels of a blood test called NT-proBNP with patient factors to calculate the probability of acute heart failure for an individual.
In this project, we wish to evaluate the performance of CoDE-HF in approximately 2,000 patients attending the Emergency Department with suspected acute heart failure. We will store surplus material from their blood tests to measure NT-proBNP and link information from their electronic health records with other routinely collected medical information in regional and national databases in order to evaluate this algorithm.
1,327 studies on the registry are indexed under Disease; 596 are open to participants now.
This study's enrollment of 3,808 is above the median of 210 across 573 observational studies indexed under Disease.
Browse Disease studies →University of Edinburgh is the lead sponsor of 393 studies on the registry; 64 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All consecutive patients presenting to the Emergency Department with acute breathlessness will be included in this study
Inclusion Criteria:
We will assess the diagnostic performance of the CoDE-HF decision support tool
Adjudicated diagnosis of acute heart failure
Time frame: At index presentation
Subsequent hospitalisation with heart failure
Time frame: 3 months
All-cause death
Time frame: 3 months
Plan to share: Undecided — IPD can be made available to researchers upon request to the principal investigator.
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Edinburgh