ClinicalTrials.gg
CompletedNCT05499299Updated Aug 16, 2022

Volatility and Heterogeneity of Vaccine Sentiments Means Continuous Monitoring is Needed When Measuring Message Effectiveness

An interventional study of Google ads in Vaccine-Preventable Diseases and Vaccine Refusal, sponsored by The University of Hong Kong. Completed at 1 site in Hong Kong. Per ClinicalTrials.gov, last updated 2022-08-16.

Sponsored by The University of Hong Kong · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Registered 1 year 1 month after the study started (first participant enrolled Jul 2021, registered Aug 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
127,000
Allocation
Randomized
Sex
All
01

Study summary

The success of vaccination programs often depends on the effectiveness of the vaccine messages, particularly during emergencies such as the COVID-19 pandemic. The current suboptimal uptake of COVID-19 vaccines across many parts of the world highlights the tremendous challenges in overcoming vaccine hesitancy and refusal even in the context of a world-devastating pandemic. The investigators conducted a randomized controlled trial in Hong Kong to evaluate the impact of seven vaccine messages on COVID-19 vaccine uptake (with the government slogan as the control). The participants included 127,000 individuals who googled COVID-19-related information during July-October 2021.

Read the detailed description

This study aims to evaluate the effectiveness of using the Google advertising platforms on influencing the uptake of COVID-19 vaccines in Hong Kong. When completed, the rich database compiled through this proposed study will provide increased insight into vaccine hesitancy in Hong Kong. Insights from the optimised online advertising trial can aid in providing crucial technical and theoretical support to the relevant health authorities for any potential evidence-based policy intervention in addressing vaccine hesitancy issues or the public's concerns towards vaccines in Hong Kong.

02

Conditions studied

  • Vaccine-Preventable Diseases
  • Vaccine Refusal

Keywords

  • Vaccine hesitancy
  • Google ads
  • Vaccine messages
  • Vaccine confidence
03

In context

Vaccine-Preventable Diseases

54 studies on the registry are indexed under Vaccine-Preventable Diseases; 14 are open to participants now.

This study's enrollment of 127,000 is above the median of 180 across 41 interventional studies indexed under Vaccine-Preventable Diseases.

Browse Vaccine-Preventable Diseases studies →

Lead sponsor

The University of Hong Kong is the lead sponsor of 1,286 studies on the registry; 343 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • General users of Google search in Hong Kong

Exclusion criteria

Exclusion Criteria:

  • None
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
127,000 participants (actual)

Study arms

  • Active comparator
    Government

    Participants were shown with the government slogan for the COVID-19 vaccine campaign in 2021. This was the control arm.

    Behavioral: Google ads

  • Experimental
    Comparison

    The ad emphasized that vaccine uptake in Hong Kong substantially lagged behind that in comparable populations such as Singapore and the UK.

    Behavioral: Google ads

  • Experimental
    Exemption

    The ad emphasized that vaccinated people could be exempted from some disruptive control measures such as mandatory testing

    Behavioral: Google ads

  • Experimental
    Family

    The ad prompted people to get vaccinated in order to protect their family.

    Behavioral: Google ads

  • Experimental
    Lottery

    The ad prompted people to get vaccinated in order to be eligible for the numerous COVID-19 lotteries in Hong Kong

    Behavioral: Google ads

  • Experimental
    Mortality

    The ad emphasized that COVID-19 has caused millions of deaths worldwide.

    Behavioral: Google ads

  • Experimental
    Reopen

    The ad prompted people to get vaccinated to help Hong Kong reopen sooner.

    Behavioral: Google ads

Interventions

  • BehavioralGoogle ads

    Individuals who googled COVID-19 information in Hong Kong were randomized to see one of the seven ads and, if they clicked on the ads, the corresponding vaccine message on our website

06

What researchers measure

Primary outcomes

  1. Number of bookings following each message delivery within 6 hours

    The number of bookings made within X = 6 hours following each message delivery

    Time frame: 6 hours

Secondary outcomes

  1. Number of bookings following each message delivery within 3 hours

    The number of bookings made within X = 3 hours following each message delivery

    Time frame: 3 hours

  2. Number of bookings following each message delivery within 12 hours

    The number of bookings made within X = 12 hours following each message delivery

    Time frame: 12 hours

07

Study locations

1 site
  • The University of Hong Kong
    Hong Kong, Hong Kong
08

References and documents

Individual participant data

Plan to share: Yes — Proposals should be directed to kathysleung@connect.hku.hk; to gain access, data requestors will need to sign a data access agreement

Supporting information: Study protocol

Time frame: Beginning 9 months and ending 36 months following article publication

Access criteria: Researchers who provide a methodologically sound proposal for meta-analysis. Proposals should be directed to Kathyleung@connect.hku.hk; to gain access, data requestors will need to sign a data access agreement.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 16, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05499299
Responsible party
Sponsor
First posted
Aug 12, 2022
Start date
Jul 1, 2021
Primary completion
Oct 31, 2021
Completion
Apr 1, 2022
Last update
Aug 16, 2022

Study contacts

Joseph T Wu, PhD
principal investigator · The University of Hong Kong

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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