New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool

• Person over 18 years old
• Patient affiliated or beneficiary of a social security scheme.
• Informed consent signed by the patient after clear and fair information about the study
• Patient registered on the list of patients who signed a doctor's statement with the investigating doctor.

• Patient with an indication for research and treatment of an Hp infection according to National Health Authority (HAS) recommendations:

  1. Suffering from (at least one) : Chronic dyspepsia; Iron deficiency anemia without a found cause or resistant to iron supplementation; Vitamin B12 deficiency without a found cause; familial gastric cancer DCDS; Immunological thrombocytopenic purpura in adulthood; history of peptic ulcers or precancerous lesions that have not been eradicated; Long-term consumption of NSAIDs; Long-term PPI consumption.

     or

  2. Patient who received Hp eradication treatment without eradication control. or

  3. Patient with risk factors for gastric cancer: person related to a patient who has had stomach cancer (parents, brothers / sisters, children).

     or

  4. Patient with a syndrome of predisposition to digestive cancers (Hereditary non-polyposis colorectal carcinoma cancer HNPCC / Lynch syndrome).

     or

  5. Patient who has had a partial gastrectomy or endoscopic treatment of gastric cancerous lesions.

     or

  6. Patient with pre-neoplastic gastric lesions (severe atrophy and / or intestinal metaplasia, dysplasia).

     or

  7. Patient who has already undergone an endoscopy with detection of Hp but without antibiotic sensitivity test (biopsy not addressed in bacteriology) and for whom we want to undergo a guided treatment.

Exclusion Criteria:

• Patient benefiting from enhanced protection, namely minors, pregnant or breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment, adults under legal protection and finally patients in emergency situations.
• Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal / mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).

Exclusion criteria related to non-compliance with ambivalence:

• Allergy to amoxicillin (suspected or documented).
• Contraindication to eso-gastro-duodenal fibroscopy and biopsies.
• Use of antibiotic within 15 days before enrolment.
• Patient with an indication to perform an endoscopy of the upper digestive system in Emergency according to the criteria of "the European Panel on the Appropriateness of Gastrointestinal Endoscopy (EPAGE II)": upper gastrointestinal hemorrhage; acute deglobulization without digestive hemorrhage externalized; ingestion of caustics; acute dysphagia or ingestion of foreign bodies.
• Participating another interventional trial