An observational study in Knee Osteoarthritis, sponsored by Pacira Pharmaceuticals, Inc. Recruiting at 19 sites in United States. Per ClinicalTrials.gov, last updated 2026-07-23.
Sponsored by Pacira Pharmaceuticals, Inc · Observational
The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA. The OA pain therapies may include cryo nerve block, radiofrequency ablation (RFA), intra-articular (IA) corticosteroids, viscosupplementation, opioids, and others (e.g., non-steroidal anti-inflammatory drugs [NSAIDs]).
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 10,000 is above the median of 100 across 486 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Pacira Pharmaceuticals, Inc is the lead sponsor of 102 studies on the registry; 3 are open to participants now.
Of its 26 completed or terminated interventional studies of FDA-regulated products, 17 (65%) have results posted.
Counted across the registry records on this site, refreshed daily.
All patients who are planned to receive treatment within 60 days of screening for knee OA pain will be screened, and if eligible, will be approached for participation in the registry.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Eligible and enrolled subjects with knee OA pain who require treatment on the target knee as a part of pain management.
Procedure: Treatment for Knee OA
Pain management treatment for knee OA.
Pain intensity and interference scores via NRS (Numeric Rating Scale)
NRS score from 0(being none)-10(being the worst)
Time frame: 18 months
Pain intensity and interference scores via BPI-sf (Brief Pain Inventory-short form)
Pain intensity and interference scores via BPI-sf 0 to 10, where: 0 = no pain and 10 = pain as bad as you can imagine
Time frame: 18 months
Opioid use via pre-and post-treatment analgesic medication use log
Opioid use via pre-and post-treatment analgesic medication use log
Time frame: 18 months
Functional status via KOOS-JR (Knee injury and Osteoarthritis Outcome Score for Joint Replacement)
Functional status via KOOS-JR. 0(none)-4(extreme)
Time frame: 18 months
Functional status via SANE (Single Assessment Numeric Evaluation)
Functional status via SANE. Percentage of normal (0% to 100% scale with 100% being normal)
Time frame: 18 months
Quality of Sleep via PROMIS-SD (PROMIS - Sleep Disturbance - Short Form 8b)
Quality of Sleep via PROMIS-SD. 1(Best)-5(Worst)
Time frame: 18 months
Adverse events related to pain therapies
Adverse events related to pain therapies
Time frame: 18 months
General HRQOL via PROMIS-10 (PROMIS GLOBAL-10)
General HRQOL via PROMIS-10. 1(Best)-5(Worst)
Time frame: 18 months
Patient Satisfaction
Patient satisfaction with pain management questionnaire (Patient Satisfaction Questionnaire). Two questions assessing satisfaction and benefit.
Time frame: 18 months
Physical therapy utilization and work productivity via PT/Work Productivity
Physical therapy (PT) utilization and work productivity via PT/Work Productivity (WP) questionnaire.
Time frame: 18 months
Emergency Department (ED) visits
Emergency Department (ED) visits
Time frame: 18 months
Reimbursement status
Reimbursement status
Time frame: 18 months
Post-operative pain scores NRS (Numeric Rating Scale)
Post-operative pain scores (NRS) 0(being none)-10(being the worst)
Time frame: 18 months
Post-operative opioid consumption (analgesic medication use log)
Post-operative opioid consumption (analgesic medication use log)
Time frame: 18 months
Length of facility stay
Length of facility stay
Time frame: 18 months
Not enrolling at this site.
Not enrolling at this site.
Not enrolling at this site.
Not enrolling at this site.
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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