An observational study in OCT Study RNFL and Macular Thickness, sponsored by Assiut University. Status unknown. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2022-08-04.
Sponsored by Assiut University · Observational
The purpose of this study is to investigate the variability of RNFL and macular thickness between myopia , hyper metropia and emmetropia
The world health organization (WHO) has estimated that the visual impairment caused by uncorrected refractive errors to be present in 153 million people worldwide (1) the prevalence of myopia ranges from 22.7% to 38.7% in large population study According to the WHO regions the estimated prevalence (EP) of hyperopia is 30.6% with the lowest EP in south east Asia 2.2% and the highest EP in the Americas 14.3% (2-3) During optic nerve development 2.85 million nerve fibers exist but by the third trimester we lose about 35% of these fibers (4) and the perpapillary retinal nerve fiber layer (RNFL) thickness will continue to decrease with advancing age (5). The relationship of the RNFL thickness with the refractive errors has been extensively investigated in adults and in children (6) and there was significant increase in the RNFL thickness in hypermetrope than in emmetrope and myope Understanding the derminants that affect the RNFL reserve helps us in the diagnosis and monitoring of optic nerve diseases. In macular region the thickness measured through optocal coherent tomography OCT shows high variability with value ranging from 190mm (centerpoint) to 389 mm (superior inner/nasal inner macula) (7) for both retinal and macular regions while decreasing in the retinal thickness has been reported with increasing age. Different studies have shown racial differences in RNFL thickness (8) white race (9) and myopia which has high prevelance in East Asian regions (10-12) have been associated with thinner RNFL (11) on the contrary Asian or Hispanic race has been associated with a thicker RNFL
140 studies on the registry are indexed under Hyperopia; 18 are open to participants now.
This study's planned enrollment of 450 is above the median of 174 across 24 observational studies indexed under Hyperopia.
Browse Hyperopia studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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patients with errors of refraction devided into 3 groups myopes (≤ -1.0 D) ; emmetropes (> -1.0 to \<
Exclusion Criteria:
Eyes with amplyopia
myopes (≤ -1.0 D)
Other: Optical cehernce tomography
hyperopia (≥ +1.0D).
Other: Optical cehernce tomography
emmetropes (\> -1.0 to \< * 1.0 D)
Other: Optical cehernce tomography
OCT macula and disc
Retinal nerve fiber layer thickness and macular thickness in myopia , hyperopia and emmetropia : An OCT study
investigate the variability of RNFL and macular thickness between myopia , hyper metropia and emmetropia The peripapillary RNFL thickness in central ,perimacular and paramacular regions will be measured using the OCT and compared between three groups of refractive states
Time frame: Baseline
No study locations are listed for this record.
This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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Assiut University