An observational study in Dementia, sponsored by Chinese University of Hong Kong. Active, not recruiting at 1 site in Hong Kong. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-15.
Sponsored by Chinese University of Hong Kong · Observational
The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.
Participants will be retrospectively selected from a Hong Kong Chinese cohort, a Singaporean cohort, a British cohort, two European cohorts, and an Australian cohort.
Subjects from the above listed cohorts who fit the study criteria will be selected for this study.
Demographical information, clinical, vascular risk factors, MRI images and cognitive data will be retrieved from the cohorts.
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's enrollment of 1,502 is above the median of 150 across 950 observational studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →Chinese University of Hong Kong is the lead sponsor of 1,419 studies on the registry; 487 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Subjects will be retrospectively selected from 7 cohorts from Hong Kong, Australia, Singapore and Europe areas.
Exclusion Criteria:
Record of any vascular risk factors
medical history of hypertension, diabetes mellitus, hyperlipidemia, smoking and drinking, record unit as yes or no
Time frame: Baseline
Record of triglyceride level
triglyceride level, as one of vascular risk factors, unit as mmol/L
Time frame: Baseline
Record of high-density-lipoprotein level,
high-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Time frame: Baseline
Record of low-density-lipoprotein level,
low-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Time frame: Baseline
Record of total cholesterol level,
total cholesterol level, as one of the vascular risk factors, unit as mmol/L
Time frame: Baseline
Record of glycated hemoglobin
glycated hemoglobin, as one of the vascular risk factors, unit as percentage
Time frame: Baseline
Record of fasting blood glucose
fasting blood glucose from blood results, as one of vascular risk factors, unit as mmol/L
Time frame: Baseline
Record of blood pressure
Blood pressure, as one of vascular risk factors, unit as mmHg
Time frame: Baseline
Record of pulse
Pulse rate, as one of vascular risk factors, unit as bpm
Time frame: Baseline
Change of Mini-Mental State Examination
Mini-Mental State Examination is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
Time frame: Baseline and 3rd year follow up
Change of Montreal Cognitive Assessment
Montreal Cognitive Assessment is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
Time frame: Baseline, 1 yr, 2yr and 3rd year follow ups
Changes of brain white matter abnormalities
brain white matter abnormalities can be observed through the FLAIR sequence of brain MRI images
Time frame: Baseline and 1 yr, 2yr and 3rd year follow ups
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Chinese University of Hong Kong